Since its inception 14 years ago, CAPRISA has conducted numerous clinical studies that have influenced international TB-HIV treatment guidelines as well as HIV prevention through innovations in the microbicide and vaccine fields. This book provides a historical account of how each of CAPRISA’s high impact studies was created, developed, implemented, analysed and communicated. In doing so, the reader is taken on a journey that provides glimpses into the genesis of research ideas and how this ultimately leads to a range of HIV prevention and treatment studies that have impacted the global response to the HIV and TB epidemics.
Comprised of 5 sections, the book details the following:
The CAPRISA Clinical Trials: HIV Treatment and Prevention is a resource for undergraduate and postgraduate students, health care providers, doctors, decision-makers and researchers who are seeking guidance and insights on clinical trials – their creation, conduct and impact.
Daftar Isi
Part I. Introduction.- Studies Linked to the Evolving HIV Epidemic in South Africa: Informing the CAPRISA Scientific Agenda.- CAPRISA: Establishing A Research Center to Undertake HIV Clinical Trials.- Overview of Clinical Trials.- Part II. CAPRISA Clinical Trials for HIV and HSV-2 Prevention.- Antiretrovirals for HIV Prevention.- Rolling out of tenofovir gel in family planning clinics: the CAPRISA 008 implementation trial.- Conditional cash transfers to reduce HIV risk in young women: the CAPRISA 007 cluster randomised control trial.- HIV vaccine and passive immunity trials.- Part III: CAPRISA Clinical Trials for HIV–TB Treatment.- CAPRISA 003: Timing of antiretroviral initiation in HIV-TB co-infected patients - The SAPi T Trial.- Scaling up TB-HIV integration in public health clinics: translating research findings into practice.- Part IV: Experiences and lessons learnt from clinical trials in CAPRISA.- Lessons from the Acute Infection Study: from Bench to Bedside.- Understanding sexual HIV transmission in women by focusing on the genital mucosa.- Part V: Essential support activities for the conduct of clinical trials.- Good practices in conducting clinical trials: Good Participatory Practice, Good Pharmacy Practice and Good Laboratory Practice.- Grants Management.- Taking science to the people: communication and media strategies for clinical trials.- Looking ahead: What Does the Future Hold for CAPRISA?.- Appendix.- Index.
Tentang Penulis
Quarraisha Abdool Karim, Centre for the AIDS Programme of Research in South Africa (CAPRISA); Department of Epidemiology, Columbia University, New York, USA
Salim S. Abdool Karim, Centre for the AIDS Programme of Research in South Africa (CAPRISA); Department of Epidemiology, Columbia University, New York, USA
Cheryl Baxter, Centre for the AIDS Programme of Research in South Africa (CAPRISA)
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