Ralph D’Agostino 
Tutorials in Biostatistics, Volume 2, Tutorials in Biostatistics [PDF ebook] 
Statistical Modelling of Complex Medical Data

The Tutorials in Biostatistics have become a very popular
feature of the prestigious Wiley journal, Statistics in
Medicine (SIM). The introductory style and practical focus make
them accessible to a wide audience including medical practitioners
with limited statistical knowledge. This book represents the
second of two volumes presenting the best tutorials published in
SIM, focusing on statistical modeling of complex data. Topics
include clustered data, hierarchical models, mixed models, genetic
modeling, and meta-analysis. Each tutorial is focused on a medical
problem, has been fully peer-reviewed and edited, and is authored
by leading researchers in biostatistics. Many articles
include an appendix on the latest developments since publication in
the journal and additional references.

This will appeal to statisticians working in medical research,
as well as statistically-minded clinicians, biologists,
epidemiologists and geneticists. It will also appeal to graduate
students of biostatistics.

Daftar Isi

Preface.

Preface to Volume 2.

Part I: MODELLING A SINGLE DATA SET.

1.1 Clustered Data.

Extending the Simple Linear Regression Model to Account for
Correlated Responses: An Introduction to Generalized Estimating
Equations and Multi-Level Mixed Modelling (Paul Burton et al).

1.2 Hierarchical Modelling.

An Introduction to Hierarchical Linear Modelling (Lisa M.
Sullivan et al).

Multilevel Modelling of Medical Data (Harvey Goldstein et
al).

Hierarchical Linear Models for the Development of Growth Curves:
An Example with Body Mass Index in Overweight /Obese Adults
(Moonseong Heo et al).

1.3 Mixed Models.

Using the General Linear Mixed Model to Analyse Unbalanced
Repeated Measures and Longitudinal Data (Avital Cnaan et al).

Modelling Covariance Structure in the Analysis of Repeated
Measures Data (Ramon C. Littell et al).

Covariance Models for Nested Repeated Measures Data: Analysis of
Ovarian Steroid Secretion Data (Taesung Park and Young Jack
Lee).

1.4 Likelihood Modelling.

Likelihood Methods for Measuring Statistical Evidence (Jeffrey
D. Blume).

Part II: MODELLING MULTIPLE DATA SETS: META-ANALYSIS.

Meta-Analysis: Formulating, Evaluating, Combining, and Reporting
(Sharon-Lise T. Normand ).

Advanced Methods in Meta-Analysis: Multivariate Approach and
Meta-Regression (Hans C. van Houwelingen et al).

Part III: MODELLING GENETIC DATA: STATISTICAL
GENETICS.

Genetic Epidemiology: A Review of the Statistical Basis (E. A.
Thompson).

Genetic Mapping of Complex Traits (Jane M. Olson et al).

A Statistical Perspective on Gene Expression Data Analysis (Jaya
M. Satagopan and Katherine S. Panageas).

Part IV: DATA REDUCTION OF COMPLEX DATA SETS.

Statistical Approaches to Human Brain Mapping by Functional
Magnetic Resonance Imaging (Nicholas Lange).

Disease Map Reconstruction (Andrew B. Lawson).

PART V: SIMPLIFIED PRESENTATION OF MULTIVARIATE DATA.

Presentation of Multivariate Data for Clinical Use: The
Framingham Study Risk Score Functions (Lisa M. Sullivan et al).

Tentang Penulis

Ralph D’Agostino, Boston University, USA
One of the editors of Statistics in Medicine and editor of the Tutorials in Biostatistics series in the journal.