Part I  Molecular bases for stem and cancer cells proliferation.- An introduction to proliferation and migration of stem cells and cancer.- the role of cell adhesions, cell junctions and extracellular matrix in normal development and carcinogenesis.- The embryonic rest hypothesis of cancer development: 150 years later.- Are calcium channels more important than calcium influx for cell proliferation ?- Role of calcium signaling in stem cells and cancer cells proliferation.- |Formation and function of lipid droplets in inflammation and cancer.- The role of sphingolipids in modulating pluripotency of stem cells.- Part II  Signaling pathways to cancer cells fate.- Signaling pathways of cbl-b and its role on peripheral t cell tolerance.- Bh3-only proteins in cancer and apoptosis.- Signaling pathways of mta family proteins as regulators of cancer progression and metastasis.- Signalling pathways of β-catenin/jnk on carcinogenesis.-  The regulation of the jnk cascade and programmed cell death by nf-κb: mechanisms and functions.- Part III Uncontrolled physiology process guiding to cancer cells.- Migration, metastasis and more: the role of chemokines in the proliferation, spreading and metastasis of tumors.- Autophagy, cell death, and cancer.- the duality of stem cells – double edged sword in tumour evolution and treatment.- Glioblastoma stem cells and implications for chemoresistance.- The tumor microenvironment as a transient niche: a modulator of epigenetic states and stem cell functions.- Tumor-associated neutrophils (tans).- Microrna control of apoptotic programs in cancer.- Part IV  Therapeutic strategies for anticancer treatment.- Markers of cancer stem cells and their functions.- Cancer cell dormancy: potential therapeutic targets to eradicate cancer cells within the niche.- Modulating apoptosis in cancer therapy with ultrasound and high intensity nanosecond electric pulses.-  Targeting cell cycle for anticancer treatment andneuroprotection.