This book provides a comprehensive overview of the approach to retroperitoneal sarcomas, rare and challenging tumors requiring highly specialized, multidisciplinary management. Based on an updated review of the literature and drawing on the expertise of respected authors, it analyzes key topics – such as pre-operative work-up and staging, multimodal therapy, multi-organ resection, surgical complications and management of local recurrence and advanced disease – as well as several other debated issues.
Presenting surgery as the cornerstone in the treatment of this disease, the book serves both as a guide for non-expert physicians wishing to understand the best management of RPS patients, including the need to refer them to specialized centers, and as a state-of-the-art overview for surgeons with interest in sarcoma surgery.
Daftar Isi
1 Introduction and history of rps sarcomas.- 2 Basics of pathology of rps and new molecular markers.- 3 Immune system and rps.- 4 Epidemiology and natural history.- 5 Diagnostic challenges, differential diagnosis and pre-operative biopsy.- 6 Patient tailored treatment (mdt meeting).- 7 resection of primary rps: surgical strategies and technique.- 8 Managing early and late postoperative complications following rps surgery.- 9 Incidence and pattern of recurrence.- 10 Management of recurrent disease.- 11 Surveillance after rps surgery.- 12 Radiation therapy for rpsin rps.- 13 Neoadjuvant and adjuvant chemoterapy in rps.- 14 Surgical resection of lung metastases.- 15 Did the outcome of rps improve in the modern era?.- 16 Quality of life and survivorship.- 17 Program of trans-atlantic retroperitoneal sarcoma working group(TARPSWG).- 18 When should you not operate a rps?.- 19 The role of patient advocacy groups.
Tentang Penulis
Vittorio Quagliuolo specialized in surgery of the digestive tract and in clinical oncology at the University of Milan. He started his career at the Istituto Nazionale dei Tumori in Milan under the direction of Prof Umberto Veronesi and mentored by Prof Leandro Gennari. His interests focused on tumors of the low rectum, hepatic metastases, and on the surgical treatment of sarcomas of the limbs, trunk and retroperitoneum, in particular on the conservative surgery of mesenchymal tumors. Since 1997 he has worked at the Humanitas Cancer Center – from 2001 to 2010 as Chief of the Sarcoma Unit and since 2011 as Director of the Division of Surgical Oncology.
He is a founding member of the European Society of Mastology (EUSOMA) and the Italian Sarcoma Group (ISG) and member of the Trans-Atlantic Retroperitoneal Sarcoma Working Group (TARPSWG). He has participated in several surgical trials of the ISG and is currently involved in the European Organization for Research and Treatment of Cancer’s STRASS trial investigating neoadivant radiotherapy in retroperitoneal sarcomas.
Alessandro Gronchi received his medical degree (high honors) in 1992 and board certification in General Surgery in 1997 from Milan University. He did a fellowship in Surgical Oncology at the National Cancer Institute – Milan – Italy in 1998. He has been chair of the Sarcoma Service at the National Cancer Institute – Milan – Italy since 2001. He has a life-time professional dedication to soft tissue sarcomas (STS), desmoid-type fibromatosis (DF) and gastrointestinal stromal tumors (GIST).He serves as chair of the STS committee of the Italian Sarcoma Group (ISG), past-chair of the EORTC-STBSG, past president of the Connective Tissue Oncology Society (CTOS) 2017, President Elect of the Italian Society of Surgical Oncology (SICO), member of the Sarcoma Disease Site Working Group of the Society of Surgical Oncology (SSO) 2018-2021; he is member of the European Society for Medical Oncology (ESMO), the European Society of Surgical Oncology (ESSO), the European Surgical Association (ESA) the American Society of Clinical Oncology (ASCO), and honorary member of the Polish Society of Surgical Oncology (PSSO). He is one of the initiators of the Trans-Atlantic Retro Peritoneal Sarcoma Working Group (TARPSWG). He has authored more than 300 scientific publications, serves as Associate Editor of the Sarcoma Journal, Journal of Surgical Oncology and Annals of Surgical Oncology.
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