A. Douglas Kinghorn & Heinz Falk 
Progress in the Chemistry of Organic Natural Products 102 [PDF ebook] 

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The first contribution reviews the phytochemical, chemical, and biological literature on members of the ingenane class of diterpenoids from their first isolation in 1968 through 2015, highlighting unresolved issues both common to phorboids and specific to ingenol derivatives. The biogenesis of ingenol is discussed in the light of the Jakupovic proposal of a dissection between the formation of the macrocyclic Euphorbia diterpenoids and the phorboids, and the clinical development of ingenol mebutate is chronicled in the light of its “reverse-pharmacology” focus.
The second contribution offers a comprehensive view of the chemical wealth and the taxonomic problems currently impeding chemical and biological investigations of the genus Laurencia. It addresses the botanical description and the growth and population dynamics of the genus, as well as its chemical diversity and ecological relations; the secondary metabolites as well as their sources of isolation; and finally the biological activity.

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Tabella dei contenuti

The
Laurencia paradox:an endless source of chemodiversity. – Ingenane Dipernoids.

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Lingua Inglese ● Formato PDF ● Pagine 252 ● ISBN 9783319331720 ● Dimensione 9.8 MB ● Editore A. Douglas Kinghorn & Heinz Falk ● Casa editrice Springer International Publishing ● Città Cham ● Paese CH ● Pubblicato 2016 ● Scaricabile 24 mesi ● Moneta EUR ● ID 4915396 ● Protezione dalla copia DRM sociale

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