A cutting-edge review of the fundamental biological principles underlying the more common inflammatory disorders of the nervous system. The authors provide extensive updates on the latest findings concerning the mechanisms of inflammation and introduce such new concepts and methodologies as ‘endothelial and leukocyte microparticles’ and ‘gene microarray technology’ to help explain important links between the central nervous system (CNS) and general inflammatory processes. Among the diseases examined from an inflammatory perspective are multiple sclerosis, acute disseminated encephalomyelitis, optic neuritis, transverse myelitis, CNS vasculitis, neuropsychiatric systemic lupus erythematosis, Alzheimer’s disease, and Parkinson’s disease. The role of the immune system in neuroinflammation is also explored in such disorders as neurosarcoidois, HIV-Associated dementia, and HTLV-associated neurological disorders.
Tabella dei contenuti
Endothelial Cell-Leukocyte Interactions During CNS Inflammation.- Multiple Sclerosis.- Cytokines and Brain.- Chemokines and Central Nervous System Disorders.- Circulating Cell-Derived Microparticles in Thrombotic and Inflammatory Disorders.- Multiple Sclerosis.- Neuroprotective Effects of Interferon-? in Multiple Sclerosis.- Acute Disseminated Encephalomyelitis.- Ingested Type I Interferon in Experimental Autoimmune Encephalomyelitis.- Neuromyelitis Optica.- Transverse Myelitis.- Optic Neuritis.- Central Nervous System Vasculitis.- Neurosarcoidosis.- Neuropsychiatric SLE.- Gene Expression in HIV-Associated Dementia.- Human T-Lymphotropic Virus-Associated Neurological Disorders.- West Nile Virus Infection of the Nervous System.
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