Bone and brain metastasis are of great importance because they can profoundly affect a patient’s quality of life and function. Complications of metastasis include pain, neurologic dysfunction and, in cases of bone metastasis, fractures and resulting loss of mobility. In particular for brain metastasis, personality and cognitive changes can affect the patient’s performance status which can jeopardise further systemic therapies aimed at prolonging survival. Ultimately, both conditions are very frightening for the cancer patient and their families. This book highlights the importance of expertise in the management of bone and brain metastasis.