Space-based Earth observations enable global observations of the land surface, biosphere, solid Earth, atmosphere, cryosphere, and oceans. Earth observations from space, combined with data acquired from in situ and ground-based instruments, help scientists understand the components of the Earth system and their interactions and enable wide-ranging applications, including forecasts of weather and air quality, projections of future climate, management of natural resources, ecological forecasting, disaster management, drought and wildfire prediction, and the mapping and prediction of vector borne/animal diseases.At the request of NASA Earth Science Division, this report assesses the potential use of a proposed multi-user, robot-tended, uncrewed commercial space platform as a potential host for a large number of Earth remote sensing instruments. Assessment of Commercial Space Platforms for Earth Science Instruments evaluates the utility and practicality of a platform in a Sun-synchronous orbit, capable of hosting 20 or more instruments.