Salivary Diagnostics surveys one of the most exciting areas of research in oral biology. Regarded as the mirror of the body, saliva has immense potential to yield real clinical improvements in our ability to diagnose, and hence treat, oral and systemic conditions. The composition of saliva and other oral fluids reflects the tissue fluid levels of therapeutic, hormonal, and immunological molecules, as well as the presence of markers for systemic and oral disease.
Tabella dei contenuti
Contributors viii
Foreword xv
Preface xvii
Acknowledgment xviii
I Background and Foundation
1 Salivary Gland Development and Regeneration 3
Sarah M. Knox and Matthew P. Hoffman
2 Salivary Gland Physiology Relevant to Diagnostics 14
Victor G. Romanenko and James E. Melvin
3 Saliva: Properties and Functions 27
Arie van Nieuw Amerongen, Enno C.I. Veerman, and Arjan
Vissink
4 Saliva Collectors 37
Arjan Vissink, Andy Wolff, and Enno C.I. Veerman
5 Salivary Secretion in Health and Disease 60
Michael D. Turner and Jonathan A. Ship
6 Processing and Storage of Saliva Samples 69
Enno C.I. Veerman, Arjan Vissink, David T. Wong, and Arie van
Nieuw Amerongen
II Saliva Diagnostics
7 Historical Perspectives and Present 79
Frank G. Oppenheim
8 Diagnostics Other Than Blood 94
Sudhir Srivastava and Karl Krueger
9 Perceptions of Saliva: Relevance to Clinical Diagnostics
104
Sreenivas Koka and David T. Wong
10 Saliva-Based Diagnostic Technologies: Highlights of the
NIDCR’s Program 111
Eleni Kousvelari, John T. Mc Devitt, Daniel Malamud, David T.
Wong, and David R. Walt
11 Human Salivary Proteomics 122
Shen Hu, Markus Hardt, Susan J. Fisher, David T. Wong, John R.
Yates, James E. Melvin, and Joseph A. Loo
12 Genomic Targets in Saliva 129
Bernhard G. Zimmermann, Zhanzhi Hu, and David T. Wong
13 Point-of-Care Diagnostics for Infectious diseases 136
Paul L.A.M. Corstjens, Daniel Malamud
14 Dental Caries Risk Assessment 150
Paul C. Denny and Patricia A. Denny
15 Periodontal Disease 156
Christoph A. Ramseier, Thiago Morelli, Janet S. Kinney, Meghan
Dubois, Lindsay Rayburn, and William Giannobile
16 Role of Saliva in Detection of Substance Abuse 169
Uttam Garg and Lance Presley
17 Head and Neck Cancer 180
Joseph A. Califano and Suhail K. Mithani
18 Sjogren’s Syndrome 189
Philip C. Fox
19 Salivary Gland Dysfunction Associated with Systemic Disease
198
Nelson L. Rhodus
20 Progression and Treatment Evaluation in Diseases Affecting
Salivary Glands 214
Jiska M. Meijer, Cees G.M. Kallenberg, and Arjan Vissink
21 The Uses of Saliva in Forensic Genetics 226
Jack Ballantyne and Jane Juusola
22 SPKB–Salivary Proteome Knowledge Base: A Platform for
Collaborative Proteomics Research 233
Weihong Yan, Weixia Yu, Shawn Than, Renli Qiao, D. Stott Parker,
Joseph A. Loo, and David T. Wong
III Saliva Diagnostics–A New Industry
23 Commercialization of Oral Fluid Products and Technologies
243
R. Sam Niedbala
24 Coverage and Reimbursement for Salivary Diagnostic Tests
255
James J. Crall
25 Saliva Diagnostics in the Dentist’s and Physician’s Office
263
Chakwan Siew and Milton V. Marshall
26 Salivary Hormones in Research and Diagnostics 270
Douglas A. Granger, Christine K. Fortunato, Leah C.
Hibel
27 Crossroads Between Saliva Diagnostics and Salivary Gland Gene
Therapy 278
Bruce J. Baum, Ana P. Cotrim, Corinne M. Goldsmith, Fumi
Mineshiba, Senrong Qi, Gabor Z. Racz, Yuval Samuni, Takayuki
Sugito, Antonis Voutetakis, and Changyu Zheng
28 Saliva Diagnostics–A New Industry 288
Stuart R. Smith, David T. Wong, and R. Michael Buch
Index 295
Circa l’autore
David Wong is Associate Dean of Research, Professor of Oral Biology, Oral Biology & Medicine, and Director of Dental Research Institute at UCLA. Dr. Wong is a dentist-scientist focusing his research on the molecular determinants (genomic and proteomic) of head and neck cancer. His research has been continuously funded by the NIDCR and NCI for the past 18 years. He has achieved two 4-year award U01 awards from the NIDCR for the creation of the UCLA Collaborative Oral Fluid Diagnostic Research Center and the Human Salivary Proteome project.
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