The pacemaking and conduction system (PCS) is vital for generating
and synchronizing the heart beat. Dysfunction of this system
can be a direct cause of cardiac conduction disturbance,
arrhythmias and sudden cardiac death. A wealth of information has
been collected over many years on the unique histological,
morphological and phenotypic characteristics of specialized cardiac
tissues. The cellular and molecular mechanisms that govern
development of the PCS are now starting to be understood.
This book draws together contributions from an international and
interdisciplinary group of experts working on both basic and
clinical aspects of cardiac development. It features reviews of the
structure and function of the developing PCS, discussion of the
molecular and cellular mechanisms regulating embryological
development of this system and studies on the fundamental
basis of PCS pathology. The book also considers how novel
therapeutic interventions based on understanding of the
developmental biology of cardiac pacemaking and conduction tissues
might ultimately impact on clinical medicine.
Tabella dei contenuti
Chair’s Introduction (R. Marwald).
The morphology of the cardiac condunction system (R. Anderson
and S. Ho).
Development of the cardiac conduction system: a matter of
chamber development (A. Moorman and V. Crhistoffels).
Mouse models for cardiac conduction system development (A.
Wessels, et al.).
Developmental transitions in cardiac conduction (M. Watanabe,
et al.).
Gap junctional connexins in developing mouse cardiac conduction
system (L. Miquerol, et al.).
His-Purkinje lineages and development (R. Gourdie, et
al.).
The role of neural crest and epicardium-derived cells in
conduction system formation (A. Gittenberger-de Groot, et
al.).
Induction and patterning of the Purkinje fibre network (T.
Mikawa, et al.).
The oldest, toughest cells in the heart (R. Thompson, et
al.).
Transcriptional regulation in the mouse atrioventricular
conduction system (A. Edwards, et al.).
Pattterning of the mouse conduction system (S. Rentschler, et
al.).
Clinical pathology of the cardiac conduction system (S. Ho).
Cardiac conduction and arrhythmia: insights from Nkx2:5
mutations in mouse and humans (P. Jay, et al.).
The genetic origin of atrio ventricular conduction disturbance
in humans (D. Benson).
Defects in cardiac conduction system lineages and malignant
arrhythmias: developmental pathways and disease (T. St. Armand et
al).
Final general discussion.
Index of contributors.
Subject index.
Circa l’autore
Derek J. Chadwick and Jamie A. Goode are editors for Development of the Cardiac Conduction System and other scientific titles.
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