Drug therapy of migraine and other headaches underwent a dramatic change in the last 10 years. This book is an overview of the drugs in the treatment of acute headache attacks and their prophylaxis. Each chapter is written by a top expert, in most cases the principal investigator of large clinical trials, and a review on the pharmacology of each substance is provided. Treatment recommendations rely on evidence-based data and are put into a clinical context. Chapters cover all the new ‘triptans’ but also more traditional drugs such as analgesics, opioids and ergots. The list of authors is the who’s who of modern headache research and practice. Physicians treating patients with headaches and pharmacologists interested in headache drugs will benefit most from this up-to-date critical overview.