Our scientific approach to depression depends on the theoretical framework available for depression and its etiology, and on the tools we have to investigate brain function. The implication of this means that models of depression will change with time. This book brings together recent updates on the main themes of depression research, presented by active researchers. One major advance has been in brain imaging. Consequently five of the chapters deal with this method, either by examining brain structure, brain function, or functional neurochemistry. A second topic is the renaissance of psychological approaches, both in terms of the neuropsychology of depression and the use of effective psychotherapy as an important adjunct to pharmacology. Recent years have seen a change from one-neurotransmitter explanations to delineating complex relationships and interaction. One such interaction, that between stressm hormones and serotonin, is explored in this volume. Finally, the role of behavioral animal models is discussed. This book will be of immense value to researchers working in the field, as well as clinicians and trainees in understanding the rationale of new diagnostic and treatment approaches. Biologists, pharmacologists and physicians will also benefit from the data on current depression research.
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