While there are a number of books on the market that deal with neuronal mechanisms and targets, the proposed book will be the only one to cover the vascular aspects of CNS trauma. The contributing authors will present basic mechanisms, explain cutting-edge experimental models and techniques, and provide several clinical chapters that provide treating physicians with some insight on the cases that they see in the ICU. The table of contents is diverse and comprehensive with chapters on molecular mechanisms, physiology, pharmacology, stem cells, genomics and proteomics, in vivo MRI and PET, as well as the clinical management of vascular parameters.
Tabella dei contenuti
CNS Barriers in Neurotrauma.- Mechanisms of Cerebral Edema Leading to Early Seizures after Traumatic Brain Injury.- Human Cerebral Blood Flow and Traumatic Brain Injury.- Gliovascular Targets in Traumatic CNS Injury.- Neurovascular Responses to Traumatic Brain Injury.- The Effects of Intravascular Coagulation and Microthrombosis on Cerebral Perfusion after Brain Trauma.- Barriers to Drug Delivery for Brain Trauma.- Angiogenesis and Functional Recovery after Traumatic Brain Injury .- Vascular Mechanisms in Spinal Cord Injury.- Neurovascular Mechanisms of Ischemia Tolerance Against Brain Injury.- Stem Cells for Neurovascular Repair in CNS Trauma.- Vascular Actions of Hypothermia in Brain Trauma.- Vascular Responses in Rodent Models of Traumatic Brain Injury.- SAH Models: Review, New Modification, and Prospective.- Age and Sex Differences In Hemodynamics In a Large Animal Model of Brain Trauma.- Neutrophils as Determinants of Vascular Stability in the Injured Spinal Cord.- Blood Biomarkers for Acute CNS Insults: Traumatic Brain Injury and Stroke.- Biomaterials for CNS Injury.- Isolated Blood Vessel Models for Studying Trauma .- Managing Edema and Intracranial Pressure in the Intensive Care Unit.- Surgical Management of Traumatic Brain Edema.- Optimizing Hemodynamics in the Clinical Setting.- Cerebrovascular Autoregulation and Monitoring of Cerebrovascular Reactivity .- Cerebrovascular Responses after Pediatric Traumatic Brain Injury.- Subdural Hematoma in Non-Accidental Head Injury.- Blood Genomics after Brain Ischemia, Hemorrhage, and Trauma.- Molecular Biomarkers in Neurocritical Care – The Next Frontier.- Bedside Monitoring of Vascular Mechanisms in CNS Trauma: The use of Near Infra-red Spectroscopy (NIRS) and Transcranial Doppler (TCD).- In vivo MRI and MRS of Cerebrovascular Function following Traumatic Brain Injury.
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