An international group of researchers addresses basic mechanism involved in the metastatic spread of tumors and considers new methods of prevention and treatment. Compares behavior of normal and abnormal cells, with emphasis on cell surface mechanisms–especially invasive processes–and inhibitors that might prevent metastasis. Also discusses determination of the metastatic genotype, the role of the immune system, and reduction of metastasis via liposome-activated macrophages.
Tabella dei contenuti
Partial table of contents:
Tissue Organizational Stability and Intercellular Invasion (P.
Armstrong).
Adhesion Mechanisms in Embryogenesis and in Cancer Invasion and
Metastasis (J. Thiery, et al.).
The Cell Interaction Sites of Fibronectin in Tumor Metastasis.
(M. Humphries, et al.).
Oncogene Induction of Metastases (L. Liotta).
Adhesive Properties of Metastasizing Tumor Cells (A. Raz).
Clonal Changes in Tumors During Growth and Progression Evaluated
by Southern Gel Analysis of Random Integrations of Foreign DNA (R.
Kerbel, et al.).
The Reversal of the Metastatic Phenotype by Gene Transfer (M.
Feldman, et al.).
Inhibitors of Collagenase IV and Cell Adhesion Reduce the
Invasive Activity of Malignant Tumor Cells (R. Reich, et
al.).
Macrophage Therapy of Cancer Metastasis (I. Fidler).
Index of Contributors.
Subject Index.
Circa l’autore
The Novartis Foundation is an international scientific and educational charity which promotes the study and general knowledge of science and in particular encourages international co-operation in scientific research.
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