John Frain 
Exploring Symptoms [PDF ebook] 
An Evidence-based Approach to the Patient History

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Understand the relationship between disease and description with this invaluable guide

Correctly interpreting patient symptoms is one of the most critical components of medical diagnosis and treatment. Though each instance of any given disease will share features with others, each patient’s experience is unique, and assessment of their condition depends on taking and interpreting an individual patient’s history. Correct diagnosis and treatment decisions rely on a sound, evidence-based approach to this crucial clinical interaction.

Exploring Symptoms – An Evidence-based Approach to the Patient History offers a rigorous analysis of the complex relationship between symptoms and patient communication. Carefully connecting basic sciences such as anatomy and physiology with the development of symptoms in each body system, this book surveys evidence for how patients tend to experience and describe symptoms and how these descriptions can shape diagnosis and treatment. It’s a must-have volume for students and clinicians looking to concretely improve patient outcomes.

Exploring Symptoms – An Evidence-based Approach to the Patient History readers will also find:


  • Detailed discussion of patient thresholds for presenting symptoms to healthcare professionals

  • Analysis of individual symptom epidemiology and its general expression at both the patient and population level

  • An inclusive approach with concrete advice for addressing the needs of a diverse patient body


Exploring Symptoms – An Evidence-based Approach to the Patient History is ideal for undergraduate and postgraduate students, as well as healthcare educators and postgraduate-allied health professionals. It is also a useful tool for early-years practitioners and general practitioners.

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Tabella dei contenuti

Preface xxiii

Abbreviations xxv

1 Exploring Symptoms 1

1.1 This History of the History 1

1.2 What Is a Symptom? 3

1.3 What Do Patients Want from Their Clinicians? 6

1.4 The Structure of a Medical History 8

1.5 Clinical Communication 11

1.6 The Opening Statement and Agreeing the Agenda 12

1.7 How Does the History Work? 15

1.8 Sources of Bias in the History 18

1.9 Ethnicity and Health 19

1.10 Statistical Concepts 23

Acknowledgements 24

References 24

2 The Skin 27

2.1 Symptoms of Skin Disease 27

2.2 About Dermatology 27

2.3 Burden of Skin Disease 28

2.4 Skin Anatomy 29

2.5 Skin Physiology 32

2.6 Assessing Skin of Colour (SOC) 32

2.7 Key Points of the History 32

2.8 The Patient Experience of Skin Disease 34

2.9 Itch (Pruritis) 34

2.10 Colour of Skin When Inflamed 37

2.11 Description of Skin Lesions 38

2.12 Assessing Conditions in Skin of Colour 38

2.13 Eczema 42

2.14 Psoriasis 44

2.15 Skin Appendages 44

2.16 Nails 45

2.17 Wounds 45

References 46

3 Respiratory 51

3.1 Ear, Nose and Throat 51

3.2 Lower Respiratory Tract 57

3.3 Anatomy and Physiology of the Lower Respiratory Tract 58

3.4 Symptoms 58

3.5 Cough 59

3.6 Breathlessness 61

3.7 Wheeze 64

3.8 Sputum 65

3.9 Haemoptysis 66

3.10 Chest Pain 69

3.11 Symptoms Clusters in Respiratory Disease 71

References 71

4 Cardiovascular 75

4.1 Global Burden of Cardiovascular Disease 75

4.2 Key Symptoms of Cardiovascular Disease 77

4.3 Prevalence of Symptoms 77

4.4 Assessment of Cardiovascular Risk 77

4.5 Pain 82

4.6 Breathlessness 90

4.7 Palpitations 93

4.8 Swelling (Oedema) 96

4.9 Syncope 99

References 101

5 Gastrointestinal 105

5.1 Overview 105

5.2 Global Burden of Gastrointestinal Disease 105

5.3 Anatomy and Function 106

5.4 Key Gastrointestinal Symptoms 108

5.5 How Common Are Gastrointestinal Symptoms? 108

5.6 Difficulty Swallowing (Dysphagia) 110

5.7 Dyspepsia 114

5.8 Nausea and Vomiting 119

5.9 Haematemesis 121

5.10 Abdominal Pain 122

5.11 Bloating and Distension 125

5.12 Change in Bowel Habit 129

5.13 Anatomy and Physiology of the Colon 130

5.14 Jaundice 132

Acknowledgements 135

References 135

6 Endocrine and Multisystem Symptoms 139

6.1 Structure and Function of the Endocrine System 139

6.2 Endocrine Symptoms 140

6.3 Burden of Disease 140

6.4 Ethnicity 142

6.5 Lgbtq+ 142

6.6 Fatigue 142

6.7 Fever/Chills/Night Sweats 146

6.8 Sepsis 149

6.9 Key Points in the History 151

6.10 Unintentional Weight Loss 151

6.11 Weight Gain 153

6.12 Dizziness 154

6.13 Thirst and Polyuria 156

6.14 Skin: Rashes/Bruising 156

6.15 Flushing 159

6.16 Long Covid 160

References 163

7 Musculoskeletal 167

7.1 Symptoms of Musculoskeletal (MSK) Disease 167

7.2 Burden of Musculoskeletal Disease 167

7.3 Community Prevalence of Symptoms 168

7.4 Distribution of Symptoms and Signs 169

7.5 Key Points in History-taking 170

7.6 Pain 171

7.7 Stiffness 173

7.8 Swelling 174

7.9 Loss of Function 175

7.10 Activities of Daily Living 176

7.11 Extra-articular Manifestations 177

7.12 Specific Joints 179

7.13 Neck 179

7.14 Thoracolumbar Spine 180

7.15 Shoulder 181

7.16 Elbow 182

7.17 Hand 182

7.18 Hip 183

7.19 Knee 183

References 186

8 Neurological 191

8.1 Impact of Neurological Disease 191

8.2 Ethnicity 191

8.3 Lgbtq+ 192

8.4 Approaching the Neurological History 192

8.5 Key Neurological Symptoms 194

8.6 Headache 194

8.7 Altered Mental Status 198

8.8 Seizures 199

8.9 Weakness 202

8.10 Sensory Symptoms 205

8.11 Tremor 206

8.12 Visual Disturbance 207

8.13 Gait Abnormality 208

8.14 Speech Abnormalities 209

References 211

9 Urinary 215

9.1 Burden of Urinary Problems 215

9.2 Community Prevalence of Urinary Symptoms 215

9.3 Ethnicity and Urinary Symptoms 216

9.4 LGBTQ+ Experience 216

9.5 Anatomy and Physiology of the Urinary Tract 217

9.6 What Causes Symptoms of the Urinary Tract? 218

9.7 Dysuria 219

9.8 Urinary Frequency 221

9.9 Urgency 222

9.10 Nocturia 223

9.11 Haematuria 224

9.12 Pain from the Urinary Tract 226

9.13 Incontinence 228

9.14 Prostatic Symptoms 230

9.15 Symptoms of Chronic Kidney Disease 232

References 233

10 Gender, Sexuality and Reproduction 237

10.1 The Scope of the Sexual History 237

10.2 Epidemiology of Gender, Sexual and Reproductive Symptoms 238

10.3 Sexual Orientation 239

10.4 Barriers to Taking a Sexual History 240

10.5 Non-consensual Sex 240

10.6 Health Professionals’ Roles in Discussion and Treatment of Non-consensual Sex 241

10.7 Gender Dysphoria 241

10.8 Vaginal Discharge 245

10.9 Normal Menstruation 247

10.10 Dysmenorrhoea 247

10.11 Heavy Menstrual Bleeding (HMB) 250

10.12 Pelvic Pain 252

10.13 Menopause 254

10.14 Sexual Dysfunction 255

10.15 Erectile Dysfunction 256

10.16 Female Sexual Dysfunction 258

10.17 Fertility Problems 259

10.18 Breast Lump 261

References 263

11 Mental Health 267

11.1 Impact of Mental Health Disorders 268

11.2 Stigma and Discrimination 271

11.3 Community Prevalence of Mental Health Symptoms 271

11.4 Social Determinants of Mental Health 271

11.5 Ethnicity and Mental Health 272

11.6 LGBTQ+ and Mental Health 272

11.7 The Patient Experience 273

11.8 Approaching the Mental Health Interview 273

11.9 Anxiety 275

11.10 Mood Disorders 276

11.11 Thought Disorder 280

11.12 Sleep Disorders 282

11.13 Memory Change 284

11.14 Personality Disorders 287

11.15 Self-harm 289

11.16 Suicide 290

11.17 Assessing Risk of Self-harm and Suicide 291

References 291

12 Babies and Children 297

12.1 Burden of Disease in Childhood 297

12.2 Social Determinants of Health 297

12.3 Ethnicity 298

12.4 Phases of Childhood 298

12.5 Exploring Symptoms of Babies and Children 299

12.6 Signs of Serious Illness in Babies 301

12.7 Feeding and Growth 301

12.8 Development 303

12.9 Cardiovascular Disease 305

12.10 Respiratory 309

12.11 Neurological 310

12.12 Gastrointestinal 311

12.13 Musculoskeletal Symptoms 312

12.14 Cancer in Children 312

12.15 Emotional Disorders 313

12.16 Autistic Spectrum Disorders (ASD) 313

12.17 Attention Deficit Hyperactivity Disorder (ADHD) 316

12.18 Adolescence 317

12.19 Gender Identity and Sexual Orientation 317

12.20 Sexual Orientation Symptoms in Children 319

References 319

13 Elderly Care 325

13.1 Global Burden of Disease in Older People 325

13.2 Ethnicity and Ageing 326

13.3 LGBTQ+ and Ageing 326

13.4 Normal Ageing 327

13.5 Symptoms in the Elderly 327

13.6 Key Tips in Taking a History 329

13.7 Multimorbidity and Comorbidity 329

13.8 Frailty 330

13.9 Falls 333

13.10 Appetite and Weight 338

13.11 Hearing and Vision 338

13.12 Mobility 339

13.13 Mental Health 340

13.14 Sexuality 341

13.15 Elder Abuse 343

References 344

14 Functional Symptoms 349

14.1 Introduction 349

14.2 Burden of Functional Disorders 350

14.3 Impact on Patients and Clinicians 350

14.4 Ethnicity and Culture 350

14.5 When Is it Organic Disease? 351

14.6 Maintaining Factors 352

14.7 Disorders of Gut-Brain Interaction (DGBI) 352

14.8 The Gut-Brain Axis 354

14.9 Irritable Bowel Syndrome (IBS) 357

14.10 Functional Dyspepsia 359

14.11 Functional Cardiovascular Symptoms 361

14.12 Functional Respiratory Symptoms 363

14.13 Functional Neurological Disorder (FND) 366

14.14 Fibromyalgia 369

14.15 Patient-Doctor Communication and Functional Symptoms 371

References 373

15 Bedside Teaching 379

Teaching About Symptoms and Diseases 379

15.1 Settings 379

15.2 Bedside Teaching 380

15.3 Organising Bedside Teaching 381

15.4 Marrying Process and Content 384

15.5 Teachable Moments 388

15.6 Topics for Reflecting on the History 389

15.7 Case-Based Discussion 394

References 394

Glossary of Terms 397

Index 401

Circa l’autore

Dr. John Frain is Clinical Associate Professor and GEM Director of Clinical Skills at the University of Nottingham, UK.

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Lingua Inglese ● Formato PDF ● Pagine 449 ● ISBN 9781394218820 ● Dimensione 11.7 MB ● Casa editrice Wiley-Blackwell ● Paese GB ● Pubblicato 2025 ● Edizione 1 ● Scaricabile 24 mesi ● Moneta EUR ● ID 10106799 ● Protezione dalla copia Adobe DRM
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