Addresses the full gamut of questions in metalloprotein
science
Formatted as a question-and-answer guide, this book examines all
major families of metal binding proteins, presenting our most
current understanding of their structural, physicochemical, and
functional properties. Moreover, it introduces new and emerging
medical applications of metalloproteins. Readers will discover both
the underlying chemistry and biology of this important area of
research in bioinorganic chemistry.
Chemistry of Metalloproteins features a building block
approach that enables readers to master the basics and then advance
to more sophisticated topics. The book begins with a general
introduction to bioinorganic chemistry and metalloproteins. Next,
it covers:
* Alkali and alkaline earth cations
* Metalloenzymes
* Copper proteins
* Iron proteins
* Vitamin B12
* Chlorophyll
Chapters are richly illustrated to help readers fully grasp all
the chemical concepts that govern the biological action of
metalloproteins. In addition, each chapter ends with a list of
suggested original research articles and reviews for further
investigation of individual topics.
Presenting our most current understanding of metalloproteins,
Chemistry of Metalloproteins is recommended for students and
researchers in coordination chemistry, biology, and medicine.
Each volume of the Wiley Series in Protein and Peptide Science
addresses a specific facet of the field, reviewing the latest
findings and presenting a broad range of perspectives. The volumes
in this series constitute essential reading for biochemists,
biophysicists, molecular biologists, geneticists, cell biologists,
and physiologists as well as researchers in drug design and
development, proteomics, and molecular medicine with an interest in
proteins and peptides.
Tabella dei contenuti
Preface ix
1 Introduction 1
Proteins: Formation, Structures, and Metalloproteins, 4
References, 28
2 Alkali and Alkaline Earth Cations 31
References, 67
3 Nonredox Metalloenzymes 71
Carboxypeptidases, 75
Carbonic Anhydrase, 84
Alcohol Dehydrogenase, 88
References, 91
4 Copper Proteins 95
Introduction, 95
Electronic Spectra of Copper Ions, 96
ESR Spectra of Copper Ions, 105
Copper Proteins, 117
Plastocyanin, 119
Azurin and Stellacyanin, 127
Superoxide Dismutase, 131
Hemocyanin, 135
Ascorbic Oxidase, 139
References, 142
5 Iron Proteins 147
Introduction, 147
Electronic Spectra of Iron Ions, 148
Mössbauer Spectroscopy of Iron Ions, 155
ESR Spectra of Iron (III), 161
Iron Bioavailability, 166
Siderophores, 171
Iron Storage and Transfer Proteins, 184
Ferritin, 184
Transferrin, 187
Dioxygenase Iron Proteins, 195
Iron-Sulfur Proteins, 207
Rubredoxin, 207
Ferredoxins, 212
2Fe-2S Ferredoxins, 212
4Fe-4S Ferredoxins, 221
Aconitase, 226
Hydroxylases, 229
Hydrogenases, 232
Nitrogenases, 240
Binuclear Iron Proteins, 251
Hemerythrin, 253
Ribotide Reductase, Purple Acid Phosphate, and Methane
Monooxygenase, 260
Hemoproteins: Classification and Behavior of Heme in Absence of
Globins, 267
Myoglobin and Hemoglobin, 275
Myoglobin, 275
Hemoglobin, 280
Cytochrome C, 298
Electron Transfer in Porphyrins and Metalloporphyrins, 301
Catalases, 311
Peroxidases, 315
Cytochrome P-450, 322
Electronic Spectra of Hemoproteins, 327
ESR Spectra of Hemoproteins, 362
References, 378
6 Vitamin B12 393
References, 405
7 Chlorophyll 407
References, 421
Index 423
Circa l’autore
JOSEPH J. STEPHANOS, PHD, is Associate
Professor of Bioinorganic, Biophysical, and Inorganic Chemistry at
Menofia University. His research examines metalloprotein chemistry,
ligand-binding, and coordination chemistry of biologically active
compounds.
ANTHONY W. ADDISON, PHD, is Professor of
Inorganic Chemistry at Drexel University. His research focuses on
bioinorganic chemistry; chemistry of dioxygen- and NO-binding
metalloproteins; and the design, synthesis, and properties of novel
chelating agents and macrocyclic and oligonuclear metal complexes.
His numerous research articles and conference presentations have
earned over 8, 000 citations and a Hirsch Index of 37.
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