Luis Antunes & David A Ferreira 
Recent Advances in BIS Guided TCI Anesthesia [PDF ebook] 

Anesthetic drugs with a rapid onset of action and a short half-live, such as the hypnotic propofol and the analgesic opioid remifentanil, allow easy control of the anesthetic depth and noxious stimuli associated to surgical interventions, and reveal most of the potential of target controlled infusion for general anesthesia. Furthermore, mathematical models were incorporated in microcomputers in delivery system devices, calculating the drug concentrations in the blood and brain, according to the infusion rate. This book approaches the characteristics of propofol and remifentanil that allow the fast emergence of target controlled infusion for general anesthesia, and its potential for closed loop control anesthesia.