This book constitutes the proceedings of the 14th International Workshop, CDMRI 2023, held in conjunction with MICCAI 2023, the 26th International Conference on Medical Image Computing and Computer-Assisted Intervention. The conference took place in Vancouver, BC, Canada, on October 8, 2023.The 17regular papers presented in this book were carefully reviewed and selected from 19 submissions. These contributions cover various aspects, including preprocessing, signal modeling, tractography, bundle segmentation, and clinical applications. Many of these studies employ novel machine learning implementations, highlighting the evolving landscape of techniques beyond the more traditional physics-based algorithms.