This report summarizes a workshop organized by the National Academies’ Roundtable on Science and Technology for Sustainability. The workshop brought together a select group of program managers from the public and private sectors to discuss specific cases of linking knowledge to action in a diverse set of integrated observation, assessment, and decision support systems. Workshop discussions explored a wide variety of experiments in harnessing science and technology to goals of promoting development and conserving the environment. Participants reflected on the most significant challenges that they have faced when trying to implement their programs and the strategies that they have used to address them successfully. The report summarizes discussions at the workshop, including common themes about the process of linking knowledge with actions for sustainable development that emerged across a wide range of cases, sectors, and regions.