This comprehensive book discusses cartilage repair and all its aspects. These aspects vary from basic insights in cartilage biology and regeneration via MRI, to results of existing cartilage repair techniques and upcoming novel approaches. Fundamental cartilage biology is the topic covered within the first chapters of the book. These chapters not only provide an insight in healthy, damaged and regenerative cartilage but also describe developments in gene therapy and methods to enhance chondrogenesis of stemcells and prevent hypertophic differentiation. There is a huge progress in the possibilities of MR imaging of both healthy, damaged and regenerative cartilage. These developments not only enable better monitoring of cartilage repair but may also unravel the pathophysiology of the development of cartilage defects. Different cartilage repair techniques (e.g. allografts, autologous chondrocytes transplantation [ACT], microfracture), there technical aspects (e.g. developments towards an total arthroscopic approach), pitfalls, and outcomes are reported in the following chapters. In these chapters factors important for the results of cartilage repair such as meniscal repair, patient factors are described. Finally, an overview of novel cartilage repair techniques such as minced cartilage, denovo cartilage and more areas are discussed in this comprehensive addition to the literature.
Tabella dei contenuti
General Introduction.- Gene Therapy in articular cartilage repair.- Targeting inflammatory processes for optimization of cartilage homeostasis and repair techniques.- Osteoarthritis: molecular mechanisms and treatments.- Bioreactor Tissue Engineering for Cartilage Repair.- Biomaterials for osteochondral reconstruction.- Advanced magnetic resonance imaging of cartilage repair.- Osteochondral Allograft Transplantation: The Rationale and Basic Science.- Osteochondral Allograft Transplantation: Surgical Technique and Results.- The Genesis of Autologous Chondrocyte Transplantation/Implantation: From a Hypothesis via an Animal Model to a Clinical Reality.- Characterized Chondrocyte Implantation challenges current paradigms for the treatment of symptomatic joint surface lesions.- Autologous Chondrocyte Implantation after Previous Treatment With Marrow Stimulation Techniques.- Arthroscopic approaches for cartilage repair in the knee joint.- Cartilage repair of the knee in athletes.- Meniscus Substitution: Scaffolds, allografts and prosthetic implants.- Cartilage Repair, Replacement, and Regenerative Strategies for Osteochondral Lesions of the Talus.- How to treat cartilage injuries in the ankle joint by BMDC’s transplantation.- Pure cartilage-based repair modalities of focal cartilage lesions.
Circa l’autore
Pieter Emans of the Department of Orthopaedic Surgery, University Hospital Maastricht, The Netherlands and Lars Peterson, Professor of Orthopaedic Surgery at University of Gothenburg, Sweden.
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