Gasotransmitters are gas molecules produced endogenously in prokaryotic and eukaryotic cells for signalling purposes. This book provides, for the first time, a comprehensive description and systematic look at all gasotransmitters, established or proposed, since their detection in 2002. The content and scope covers the production, metabolism, and signalling roles of gasotransmitters. Conceptual advances, scientific discoveries and newly developed techniques described in this book influence our understanding of fundamental molecular and cellular events in biology and medicine.
This book serves as the state-of-the-art book for undergraduate and graduate students as well as post-doctoral fellows in biomedical disciplines and toxicologists studying the toxic mechanisms of gasotransmitters in the environment. It will also be welcomed by researchers in university and research institutes, government agencies, pharmaceutical and medical instrument industry, and clinical practice.
Tabella dei contenuti
Overview of Gasotransmitters and the Related Signaling Network; Production of NO – The L-arginine/NOS/NO System; Production of H2S – The L-cysteine/CSE-CBS-MST/H2S System; HO-1-derived CO is a Regulator of Vascular Function and Metabolic Syndrome; Production and Signalling Functions of Ammonia in Mammalian Cells; The Interaction of NO and H2S Signaling Systems in Biology and Medicine; Signaling by CO: Molecular and Cellular Functions; Production and Signalling of Methane; Gasotransmitters in Plants
Circa l’autore
Dr Rui Wang has been Vice-President of Research of Laurentian University since January of 2015. From 2004 to 2014, Dr Wang served as the Vice President of Research firstly, and then as Vice President of Research, Economic Development and Innovation at Lakehead University. Dr Wang came to Lakehead from the University of Saskatchewan, where he was a Professor of Physiology and leader of both the Cardiovascular Research Group and the Cardiovascular and Respiratory Network. Prior to that, Dr Wang was a Principal Investigator from 1995 to 2000 at the Mount Desert Island Biological Laboratory in Maine, USA, and an Assistant Professor at the Université de Montréal from 1993 to 1997. Dr Wang was trained in China as a medical doctor, and later received his Ph D degree in 1990 from the University of Alberta. Dr Wang is an international leader in the study of the metabolism and physiological functions of a group of small molecules of gas, known as gasotransmitters
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