Neurotransmitters are usually considered to be endogenous substances that are released from neurons, act on receptor sites that are typically present on membranes of postsynaptic cells and produce a functional change in the properties of the target cell. They are essential features of the nervous systems of all animals, and numerous chemicals can act as neurotransmitters either intentionally (e.g. pesticides) or unintentionally (neurotoxins). The most common forms of neurotoxicity are the death of neurons, degeneration of axons, damage to glial cells and interference with the axonal membrane or neurotransmission. Important neurotoxins are found among pesticides, metals, solvents, natural substances, and industrial chemicals. Environmental chemicals may also contribute to the pathology of neurodevelopmental, neuropsychiatric, and neurodegenerative disorders. Neurotransmitters and Toxicology will be particularly appealing to toxicologists interested in neurotoxicology in various sub-disciplines, as well as neuro-chemists interested in pathology and disease mechanisms associated with neurotoxicants.
Tabella dei contenuti
Introduction;Cholinergic Neurotransmission;Cholinergic Neurotransmission and Toxicity – Neonicotinoids and Spinosad;Glutamatergic Neurotransmission and Toxicity: Domoic Acid and Kainic Acid (Glutamic Acid Analogs);GABAergic Neurotransmission and Toxicity 1: Organochlorines;GABAergic Neurotransmission and Toxicity 2: Macrocyclic Lactones;GABAergic Neurotransmission and Toxicity 3: Isoxazolines;Monoamine Neurotransmission and Toxicity;Cannabinoid Neurotransmission: Neurotoxicity or Neuroprotection
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KNW Animal Health Consulting, UK
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