In this fast moving field the main goal of this volume is to provide up-to-date information on the molecular and functional properties and pharmacology of mammalian TRP channels. Leading experts in the field have written 35 essays which describe properties of a single TRP protein/channel or portray more general principles of TRP function and important pathological situations linked to mutations of TRP genes or their altered expression. Thereby this volume on Transient Receptor Potential (TRP) Channels provides valuable information for readers with different expectations and backgrounds, for those who are approaching this field of research as well as for those wanting to make a trip to TRPs, from pharmacologists and physiologists to medical doctors, other scientists, students and lecturers. It fills a gap between pharmacology textbooks and latest manuscripts in scientific periodicals.
Tabella dei contenuti
An Introduction on TRP Channels.- An Introduction on TRP Channels.- TRPC Channel Subfamily.- TRPC1 Ca2+-Permeable Channels in Animal Cells.- TRPC2: Molecular Biology and Functional Importance.- TRPC3: A Multifunctional, Pore-Forming Signalling Molecule.- Ionic Channels Formed by TRPC4.- Canonical Transient Receptor Potential 5.- TRPC6.- TRPC7.- TRPV Channel Subfamily.- Capsaicin Receptor: TRPV1 A Promiscuous TRP Channel.- 2-Aminoethoxydiphenyl Borate as a Common Activator of TRPV1, TRPV2, and TRPV3 Channels.- TRPV4.- TRPV5, the Gateway to Ca2+ Homeostasis.- TRPV6.- TRPM Channel Subfamily.- TRPM2.- TRPM3.- Insights into TRPM4 Function, Regulation and Physiological Role.- TRPM5 and Taste Transduction.- TRPM6: A Janus-Like Protein.- The Mg2+ and Mg2+-Nucleotide-Regulated Channel-Kinase TRPM7.- TRPM8.- Other TRP Channels.- TRPA1.- TRPP2 Channel Regulation.- TRP Proteins and Specific Cellular Functions.- Know Thy Neighbor: A Survey of Diseases and Complex Syndromes that Map to Chromosomal Regions Encoding TRP Channels.- TRP Channels of the Pancreatic Beta Cell.- TRP Channels in Platelet Function.- TRP Channels in Lymphocytes.- Link Between TRPV Channels and Mast Cell Function.- TRPV Channels’ Role in Osmotransduction and Mechanotransduction.- Nociception and TRP Channels.- TRP Proteins — Integrators of Multiple Inputs.- Regulation of TRP Ion Channels by Phosphatidylinositol-4, 5-Bisphosphate.- TRPC, c GMP-Dependent Protein Kinases and Cytosolic Ca2+.- Trafficking of TRP Channels: Determinants of Channel Function.- TRPC Channels: Interacting Proteins.- TRPC Channels: Integrators of Multiple Cellular Signals.- Phospholipase C-Coupled Receptors and Activation of TRPC Channels.- Erratum.- Erratum.
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