This practical guide to pharmacology is unusual in its approach. Instead of examining the normal effects of drugs this book looks at the adverse effects. With the advent of nurse prescribing it is essential that nurses are familiar with the common adverse effects, how to recognise them and how to deal with them. The book is divided into three sections. The first examines the pharmacology of drugs i.e. what the body does to drugs (pharmocokinetics), what the drugs do to the body (pharmocodynamics), and how adverse reactions can result from these two processes. Section two looks at putting the scientific knowledge into action through an examination of nurse administration and prescribing, drug development and the issue of patient compliance and empowerment. Section three consists of twelve case studies which describe various scenarios in which there have been adverse drug effects. Throughout the book concepts are explained using examples so that the nurse can relate the concept of adverse effect to the drugs she is familiar with.
Table of Content
Preface ix
Introduction xi
PART 1 THE SCIENCE OF ADVERSE DRUG EFFECTS
Chapter 1 Pharmacokinetic effects – absorption and distribution 3
Chapter 2 Pharmacokinetic effects – metabolism and excretion 24
Chapter 3 Pharmacodynamics and receptors 37
Chapter 4 Pharmacodynamics, enzymes, ion channels and carriers 44
Chapter 5 Idiosyncratic effects and drug allergy 52
Chapter 6 Client groups 67
Chapter 7 Gastro-intestinal and hepatic effects 90
Chapter 8 Renal effects 111
Chapter 9 Cardiovascular and respiratory effects 128
Chapter 10 Neurological, sensory and endocrine effects 150
Chapter 11 Psychological effects 172
Chapter 12 Effects on the skin and musculoskeletal system 186
Chapter 13 Effects on the reproductive system and sexuality 202
Chapter 14 Drug resistance 215
PART 2 THE ART OF ADVERSE DRUG EFFECTS
Chapter 15 Nurse administration and prescribing 227
Chapter 16 Ethics of drug development and testing 241
Chapter 17 Compliance, patient education and empowerment 252
Chapter 18 Complementary therapy — Debrae Ward-Walsh 268
PART 3 THE PRACTICE — 12 CASE STUDIES
Chapter 19 Assessment issues 287
Chapter 20 Drug interactions 297
Chapter 21 Drug misuse 310
Chapter 22 Empowerment 323
Abbreviations and Glossary 336
Index 341
About the author
Jennifer Kelly is the author of Adverse Drug Effects: A Nursing Concern, published by Wiley.
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