This title is a comprehensive text that addresses key aspects of nanomedicine such as properties occurring at the nanoscale that have unique medical effects, great molecular knowledge of the human body and disease processes, and apparent clinical translation as opposed to narrow insufficient texts that address only a few topics and attempt to “rebrand” established drug delivery. It will clearly define the field which is needed due to the immaturity and broad nature of the field. The book is aligned with both the USA and European roadmaps for nanomedicine and will address initiatives taken in Asia that ensures timely and relevant content. In-depth chapters ensure each section is adequately covered. The nanopharmaceutical section focuses on novel drug delivery systems relevant to nanomedicine and the book has an extensive section on immune recognition at the nanoscale which has implications for in vivo applications of nanomedicines.
Table of Content
1 Nanomedicine: working towards defining the field.- 2 Complement regulators and inhibitors in health and disease: A structural perspective.- 3 The art of complement: complement sensing of nanoparticles and consequences.- 4 The nanoscience of polyvalent binding by proteins in the immune response .- 5 Microfluidics-based Single Cell Analytical Platforms for Characterization of Cancer.- 6 Nanotheranostics and in-vivo imaging.- 7 Targeting cancer using nanocarriers.- 8 The importance of particle geometry in design of therapeutic and imaging nanovectors.- 9 Delivery of peptides and proteins to the brain using nano-drug delivery systems and other formulations.- 10 Polymer-based DNA delivery systems for cancer immunotherapy.- 11 The use of silk in nanomedicine applications.- 12 Nanotoxicology and regulatory affairs.- 13 The application of nanotechnology for implant drug release.- 14 Guided cellular responses by surface cues for nanomedicine applications
About the author
Kenneth Alan Howard is an Associate Professor and Group Leader at the Department of Molecular Biology at the Interdisciplinary Nanoscience Center (i NANO), Aarhus University, Denmark. His research and teaching activities are focused on delivery science, nanomedicine and RNA interference. Kenneth Alan Howard received a Ph D in Pharmaceutical Science from the University of Nottingham, UK, and has held postdoctoral positions at the CRC Institute for Cancer Studies, University of Birmingham, UK and the School of Pharmacy, University of London. Dr Howard is an active member of the Controlled Release Society serving on the Board of Scientific Advisors (chair), Nominations Committee and organizer of a CRS Educational workshops “RNA Interference Biology and Therapeutics” and “Albumin: the next generation therapeutic.
Dan Peer is a translational scientist and Professor that leads an NIH-funded lab in the Faculty of Life Science and the Faculty of Engineering at Tel Aviv University (TAU). He is also the Director of the Focal Technology Area (FTA) on Nanomedicines for Personalized Theranostics, a National Nanotechnology Initiative and the Director of the Leona M. and Harry B. Helmsley Nanotechnology Research Fund. Prof. Peer’s work was among the first to demonstrate systemic delivery of RNAi molecules using targeted nanocarriers to the immune system and he pioneered the use of RNA interference (RNAi) for in vivo validation of new drug targets within the immune system. He is an editor of several books in the field of nanomedicine, Editor of Molecular and Cellular Therapies (Springer); Editor of Biology and Medicine in Nanotechnology (IOP), an Associate Editor of the Journal of Controlled Release (Elsevier); Journal of Biomedical Nanotechnology, and of Biochemistry, and on the Editorial Boards of the Biomedical Microdevices (Springer), Cancer Letters (Elsevier), Nanomedicine: Nanotechnology, Biology and Medicine (Elsevier) and Bioconjugate Chemistry (ACS). Prof. Peer is currently the President of the Israeli Chapter of the Controlled Release Society, and a Member of the Israel Young Academy of Sciences and Humanities.
Thomas Vorup-Jensen is head of the Biophysical Immunology Laboratory in Department of Biomedicine and a member of the i NANO at Aarhus University. He received a Ph D in medicine from Aarhus University on topics involving the discovery, characterization and recombinant manufacture of molecules of the complement system. More recently, he was awarded from the same institution the Doctor of Medical Science degree following a dissertation on polyvalent interactions between molecules of the immune system and their targets, which includes certain nanomedicines. Following his work as Research Fellow in Pathology with Harvard Medical School and later employment with Aarhus University, his research has focused on understanding the nanoscience of protein ligand recognition. In addition to his academic efforts, Prof. Vorup-Jensen and his laboratory actively collaborate with industry partners to translate scientific findings into new treatments of clinical unmet needs, in particular focusing on autoimmune and infectious diseases. Prof. Vorup-Jensen is on the editorial boards of Frontiers in Pharmacology, Frontiers in Immunology, and Molecular and Cellular Therapies. Prof. Vorup-Jensen was recently elected member of The Danish Academy of Natural Sciences.
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