This comprehensive survey systematically explores the dynamic historic and contemporary interface between Mexico and the United States along the shared 1, 954-mile international land boundary. Now fully updated and revised, the book provides an overview of the history of the region and traces the economic cycles and social movements from the 1880s through the second decade of the twenty-first century. The border region shares characteristics of both nations while maintaining an internal social and economic coherence that transcends its divisive international boundary. The authors conclude with an in-depth analysis of key contemporary issues. These include industrial development and manufacturing, bilateral trade, the United States-Mexico-Canada Agreement, rapid urbanization, border culture, population and migration issues, environmental crisis and climate change, Native Americans, cooperation and conflict at the border, drug trafficking and violence, the border wall and security, populist national leaders and the border, and the Covid-19 pandemic at the border. They also place the border in its global context, examining it as a region caught between the developed and developing world and highlighting the continued importance of borders in a rapidly globalizing world. Richly illustrated with photographs, maps, charts, and up-to-date statistical tables, this book is an invaluable resource for all those interested in borderlands and U.S.-Mexican relations.