This volume includes ten chapters that present recent research advances in health and disease. Chapter One reviews the importance of 5alpha-reductase inhibitors, with focus on oxidized steroidal derivatives, for treatment of prostatic diseases. Chapter Two examines inflammation in chronic obstructive pulmonary disease. Chapter Three indicates plausible mechanistic insights of binding of vitamin B12 and its precursor cobinamide. Chapter Four summarizes fluid therapy for treatment of traumatic brain injury. Chapter Five explores the healthcare response to COVID-19 in Bhutan and Nepal. Chapter Six examines changes in immune function associated with aging. Chapter Seven discusses the epidemiology, clinical features, investigations, and management of pyogenic spondylodiscitis. Chapter Eight describes the characterization of vitamin B12 compounds in food. Chapter Nine discusses the use of tryptophan to manage biofilms. Finally, Chapter Ten discusses targeting nuclear factor erythroid 2-related factor 2 by synthetic and natural agents and its impact on multiple sclerosis.
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