Provides expert, state-of-the-art insight into the current
progress of viral and non-viral gene therapy
Translational medicine has opened the gateway to the era of
personalized or precision medicine. No longer a one-size-fits-all
approach, the treatment of cancer is now based on an understanding
of underlying biologic mechanisms and is increasingly being
tailored to the molecular specificity of a tumor.
This book provides a comprehensive overview of the pertinent
molecular discoveries in the cancer field and explains how these
are being used for gene-based cancer therapies. Designed as a
volume in the Translational Oncology book series, Cancer Gene
Therapy by Viral and Non-viral Vectors deals with the practice
of gene-therapy, with reference to vectors for gene expression and
gene transfer, as well as viral therapy. It covers the history and
current and future applications of gene transfer in cancer, and
provides expert insight on the progress of viral and non-viral gene
therapy with regard to delivery system, vector design, potential
therapeutic genes, and principles and regulations for cancer gene
therapy.
Presented in three parts, Cancer Gene Therapy by Viral and
Non-viral Vectors covers:
Delivery Systems
* Translational Cancer Research: Gene Therapy by Viral
and Non-viral Vectors
* Retroviruses for Cancer Therapy
* DNA Plasmids for Non-viral Gene Therapy of
Cancer
* Cancer Therapy with RNAi delivered by Non-viral
Membrane/Core Nanoparticles
Targeted Expression
* Cancer Gene Therapy by Tissue-specific and
Cancer-targeting Promptors
* Micro RNAs as Drugs and Drug Targets in Cancer
Principles of Clinical Trials in Gene Therapy
* Regulatory issues for Manufacturers of Viral Vectors
and Vector-transduced Cells for Phase I/II Trials
* US Regulations Governing Clinical Trials in Gene
Therapy
* Remaining Obstacles to the Success of Cancer Gene
Therapy
Focusing on speeding the process in clinical cancer care by
bringing therapies as quickly as possible from bench to bedside,
Cancer Gene Therapy by Viral and Non-viral Vectors is an
absolutely vital book for physicians, clinicians, researchers, and
students involved in this area of medicine.
Table of Content
List of Contributors, vii
Series Foreword, ix
Preface, xi
Part I Delivery Systems
1 Translational Cancer Research: Gene Therapy by Viral and
Non-viral Vectors, 3
Vincenzo Cerullo, Kilian Guse, Markus Vähä-Koskela,
and Akseli Hemminki
2 Retroviruses for Cancer Therapy, 21
Jiehua Zhou, Yue Ding, John C. Burnett, and John Rossi
3 DNA Plasmids for Non-viral Gene Therapy of Cancer, 39
Amer M. Najjar, Judy S.E. Moyes, and Laurence J.N.
Cooper
4 Cancer Therapy with RNAi Delivered by Non-viral Membrane/Core
Nanoparticles, 61
Andrew B. Satterlee and Leaf Huang
Part II Targeted Expression
5 Cancer Gene Therapy by Tissue-specific and Cancer-targeting
Promoters, 81
Jennifer L. Hsu, Longfei Huo, Chia-Wei Li, Yi-Hsin Hsu, Yan
Wang, and Mien-Chie Hung
6 Micro RNAs as Drugs and Drug Targets in Cancer, 97
Hui Ling and George A. Calin
Part III Principles of Clinical Trials in Gene
Therapy
7 Regulatory Issues for Manufacturers of Viral Vectors and
Vector-transduced Cells for Phase I/II Trials, 115
Adrian P. Gee and Zhuyong Mei
8 US Regulations Governing Clinical Trials in Gene Therapy,
131
Bambi Grilley
9 Remaining Obstacles to the Success of Cancer Gene Therapy,
151
Malcolm K. Brenner
Index, 157
About the author
Edited by
Malcolm K. Brenner, MB, BChir, Ph D, Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX, USA
Mien-Chie Hung Ph D, Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
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