Frogs from the genus Xenopus have long been used as model
organisms in basic and biomedical research. These frogs have helped
unlock key fundamental developmental and cellular processes that
have led to important scientific breakthroughs and have had
practical application in embryology, cancer research and
regenerative medicine. Xenopus Development is a vital
resource on the biology and development of these key model
organisms, and will be a great tool to researchers using these
frogs in various disciplines of biological science.
Xenopus Development is divided into four sections, the
first three highlight key processes in Xenopus development from
embryo to metamophosis. These sections focus on the cellular
processes, organogenesis and embryo development. The final section
highlights novel techniques and approaches being used in Xenopus
research.
Providing thorough and detailed coverage, Xenopus
Development, will be a timely and welcome volume for those
working in cell and molecular biology, genetics, developmental
biology and biomedical research.
* Provides broad overview of the developmental biology of both
Xenopus laevis and Xenopus tropicalis
* Explores cellular to systems development in key biomedical
model organisms
* Timely synthesis of the field of Xenopus biology
* Highlights key biomedical and basic biological findings
unlocked by Xenopus
Table of Content
Contributors vii
Preface ix
Section I Oocyte and Early Embryo 1
1 Transcription in the Xenopus Oocyte Nucleus 3
Joseph G. Gall
2 RNA Localization during Oogenesis in Xenopus laevis 16
James O. Deshler
3 From Oocyte to Fertilizable Egg: Regulated m RNA Translation
and the Control of Maternal Gene Expression 38
Chad E. Cragle & Angus M. Mac Nicol
4 Polarity of Xenopus Oocytes and Early Embryos 60
Malgorzata Kloc
5 Germ-Cell Specification in Xenopus 75
Mary Lou King
Section II Midblastula Transition, Gastrulation, and
Neurulation 101
6 The Xenopus Embryo as a Model System to Study Asymmetric
Furrowing in Vertebrate Epithelial Cells 103
Jacek Z. Kubiak, Isabelle Chartrain, & Jean-Pierre
Tassan
7 Induction and Differentiation of the Xenopus Ciliated
Embryonic Epidermis 112
Marie Cibois, Pierluigi Scerbo, Virginie Thomé, Andrea
Pasini, & Laurent Kodjabachian
8 Wnt Signaling during Early Xenopus Development 130
François Fagotto
9 Neural Tube Closure in Xenopus 163
Hitoshi Morita, Makoto Suzuki, & Naoto Ueno
Section III Metamorphosis and Organogenesis 187
10 Primordial Germ Cell Migration 189
Aliaksandr Dzementsei & Tomas Pieler
11 Development of Gonads, Sex Determination, and Sex Reversal in
Xenopus 199
Rafa³ P. Piprek & Jacek Z. Kubiak
12 The Xenopus Pronephros: A Kidney Model Making Leaps toward
Understanding Tubule Development 215
Rachel K. Miller, Moonsup Lee, & Pierre D. Mc Crea
13 Development of Neural Tissues in Xenopus laevis 239
William A. Muñoz, Amy K. Sater, & Pierre D.
Mc Crea
14 The Development of the Immune System in Xenopus 264
Louis Du Pasquier
15 Neural Regeneration in Xenopus Tadpoles during Metamorphosis
293
Mauricio Moreno, Karina Tapia, & Juan Larrain
Section IV Novel Techniques and Approaches 309
16 Atomic Force Microscopy Imaging of Xenopus laevis Oocyte
Plasma Membrane 311
Francesco Orsini
17 Size Scaling of Subcellular Organelles and Structures in
Xenopus laevis and Xenopus tropicalis 325
Lisa J. Edens & Daniel L. Levy
18 A Model for Retinal Regeneration in Xenopus 346
Masasuke Araki
19 The Xenopus Model for Regeneration Research 368
Ying Chen & Gufa Lin
20 Genomics and Genome Engineering in Xenopus 383
Léna Vouillot, Aurore Thélie, Thibault Scalvenzi,
& Nicolas Pollet
Index 403
About the author
Malgorzata Kloc is the Weill Cornell Professor of Cell and Molecular Biology and Director of the Immuno-Biology Laboratory at the Houston Methodist Hospital Research Institute and Adjunct Associate Professor at the University of Texas M D Anderson Cancer Center
Jacek Z. Kubiak is a DR2 Researcher in the CNRS at the Institute of Genetics and Development and at the University of Rennes 1
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