Men in America today may have advantages that women lack. However, in spite of these advantages, men die at a younger age on average than women; men are also more likely than women to have a substance use disorder, to be incarcerated, to be homeless as adults, to die of suicide, and to be victims of violent crime. Conversely, men are less likely than women to seek medical help or behavioral health counseling for any of the problems they face. These significant problems, combined with men’s tendency to avoid addressing them, call for a response from behavioral health treatment providers. This book provides an overview of the diverse problems that men with substance use disorders face and serves as both an introduction to the topic and a summary of what is known regarding the subject to date.