This book contains the refereed contributions from the 42nd annual meeting of ISOTT. The annual meetings of ISOTT bring together scientists from various fields (medicine, physiology, mathematics, biology, chemistry, physics, engineering, etc.) in a unique international forum. ISOTT conferences are a place where an atmosphere of interaction is created, where many questions are asked after each presentation and lively discussions occur at a high scientific level. This vivid interaction is the main motivation for members to participate and gain new ideas and knowledge in the broad field of oxygen transport to tissue. The papers in this volume summarize some of the outstanding contributions from the 42nd annual meeting, which included sessions on: cellular hypoxia and mitochondria; blood substitutes and oxygen therapeutics; oxygen transport in critical care medicine and disease; muscle oxygenation; multi modal imaging techniques; brain oxygenation and imaging; optical techniques for oxygen measurement; microcirculation; mathematical modelling of oxygen transport; and cancer metabolism.
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The Most Important Discovery of Science.- The Spatial Distribution of Absolute Skeletal Muscle Deoxygenation during Ramp-incremental Exercise Is Not influenced by Hypoxia.- Do Two Tissue Blood Volume Parameters Measured by Different Near-infrared Spectroscopy Methods Show the Same Dynamics During Incremental Running?.- Underwater Near-infrared Spectroscopy: Muscle Oxygen Changes in the Upper and Lower Extremities in Club Level Swimmers and Triathletes.- Muscle Oxygenation During Running Assessed By Broad Band NIRS.- Regional Differences in Muscle Energy Metabolism in Human Muscle by 31P-Chemical Shift Imaging.- Sex-related Difference in Muscle Deoxygenation Responses between Aerobic Capacity-matched Elderly Men and Women.- Effects of Low Volume Aerobic Training on Muscle Desaturation during Exercise in Elderly Subjects.- Differences in Contraction-induced Hemodynamics and Surface EMG in Duchenne Muscular Dystrophy.- Changes in Cortical Oxyhaemoglobin Signal during Low-intensity Cycle Ergometer Activity: A Near-infrared Spectroscopy Study.- Validation of a New Semi-automated Technique to Evaluate Muscle Capillarization.- Reduction in Cerebral Oxygenation after Prolonged Exercise in Hypoxia Is Related to Changes in Blood Pressure.- The Pathway for Oxygen: Tutorial Modelling on Oxygen Transport from Air to Mitochondrion.- Simulation of Preterm Neonatal Brain Metabolism during Functional Neuronal Activation Using a Computational Model.- Hemoglobin Effects on Nitric Oxide Mediated Hypoxic Vasodilation.- A Discussion on the Regulation of Blood Flow and Pressure.- Near-infrared Light Scattering Changes Following Acute Brain Injury.- Comparison of Cerebral Oxygen Saturation and Cerebral Perfusion Computed Tomography in Cerebral Blood Flow in Patients with Brain Injury.- Detection of ROSC in Patients with Cardiac Arrest during Chest Compression using NIRS: A Pilot Study.- Myocardial Microcirculation and Mitochondrial Energetics in the Isolated Rat Heart.- Tissue Discs: A 3DModel for Assessing Modulation of Tissue Oxygenation.- Hypoxia-driven Adenosine Accumulation: A Crucial Microenvironmental Factor Promoting Tumor Progression.- Approaching Oxygen-guided Intensity-modulated Radiation Therapy.- Hypoxia-associated Marker CA IX Does Not Predict the Response of Locally Advanced Rectal Cancers to Neoadjuvant Chemoradiotherapy.- Impact of Oxygenation Status on 18F-FDG Uptake in Solid Tumors.- Direct Evidence of the Link between Energetic Metabolism and Proliferation Capacity of Cancer Cells In Vitro.- Acidosis Promotes Metastasis Formation by Enhancing Tumor Cell Motility.- Preoperative Stress Conditioning in Humans: Is Oxygen the Drug of Choice?.- In Vivo Imaging of Flavoprotein Fluorescence during Hypoxia Reveals the Importance of Direct Arterial Oxygen Supply to Cerebral Cortex Tissue.- Cardiovascular Adaptation in Response to Chronic Hypoxia in Awake Rats.- Prototyping the Experimental Setup to Quantify the Tissue Oxygen Consumption Rate and Its Preliminary Test.- Monitoring Intracellular Oxygen Concentration: Implications for Hypoxia Studies and Real-time Oxygen Monitoring.- Aging Effect on Post-recovery Hypofusion and Mortality following Cardiac Arrest and Resuscitation in Rats.- Using f NIRS to Study Working Memory of Infants in Rural Africa.- Gender and Age Analyses of NIRS/STAI Pearson Correlation Coefficients at Resting State.- Effects of Cosmetic Therapy on Cognitive Function in Elderly Women Evaluated by Time-resolved Spectroscopy Study.- Effects of Acupuncture on Anxiety Levels and Prefrontal Cortex Activity Measured by Near-infrared Spectroscopy: A Pilot Study.- Influence of Pleasant and Unpleasant Auditory Stimuli on Cerebral Blood Flow and Physiological Changes in Normal Subjects.- Spontaneous Fluctuations of PO2 in the Rabbit Somatosensory Cortex.- Effect of the Antioxidant Supplement Pyrroloquinoline Quinone Disodium Salt (Bio PQQTM) on Cognitive Functions.- Estimation of Skin Blood Flow Artefacts in NIRS Signals during a Verbal Fluency Task.- Effect of Transcranial Direct Current Stimulation over the Primary Motor Cortex on Cerebral Blood Flow: A Time Course Study Using Near-infrared Spectroscopy.- Relationships between Gum-chewing and Stress.- Effects of Anodal High-definition Transcranial Direct Current Stimulation on Bilateral Sensorimotor Cortex Activation During Sequential Finger Movements: An f NIRS Study.- Towards Human Oxygen Images with Electron Paramagnetic Resonance Imaging .- Evaluation of Brown Adipose Tissue Using Near-infrared Time-resolved Spectroscopy.- Near-Infrared Image Reconstruction of Newborns’ Brains: Robustness to Perturbations of the Source/Detector Location.- Simultaneous Measurement of Dissolved Oxygen Pressure and Oxyhemoglobin Spectra in Solution.- Local Measurement of Flap Oxygen Saturation: An Application of Visible Light Spectroscopy.- Hemodynamic Measurements of the Human Adult Head in Transmittance Mode by Near-infrared Time-resolved Spectroscopy.- Non-Invasive Monitoring of Hepatic Oxygenation Using Time-resolved Spectroscopy.- Comparison of Near-infrared Oximeters in a Liquid Optical Phantom with Varying Intralipid and Blood Content.- Improvement of Speckle Contrast Image Processing By An Efficient Algorithm.- A Clinical Tissue Oximeter using NIR Time-resolved Spectroscopy.- Validation of a Hybrid Microwave-Optical Monitor to investigate Thermal Provocation in the Microvasculature.- Possibilities of Using Fetal Hemoglobin as a Platform for Producing Hemoglobin-based Oxygen Carriers (HBOCs).- The βLys66Tyr Variant of Human Hemoglobin as a Component of a Blood Substitute.- PEGylated Bovine Carboxyhemoglobin (SANGUINATE™): Results of Clinical Safety Testing and Use in Patients: An Easy Guide.- Oxygen Supplementation Is Effective in Attenuating Maternal Cerebral Blood Deoxygenation after Spinal Anesthesia for Cesarean Section.- Changes in Cerebral Blood Flow and Oxygenation during Induction of General Anesthesia with Sevoflurane versus Propofol.- Neurovascular Interactions in the Neurologically Compromised Neonatal Brain.- In vivo Measurement of Cerebral Mitochondrial Metabolism Using Broadband Near Infrared Spectroscopy following Neonatal Stroke.- A New Framework for the Assessment of Cerebral Hemodynamics Regulation in Neonates Using NIRS.- Characterizing Fluctuations of Arterial and Cerebral Tissue Oxygenation in Preterm Neonates by Means of Data Analysis Techniques for Nonlinear Dynamical Systems.- Can the Assessment of Spontaneous Oscillations by Near Infrared Spectrophotometry Predict Neurological Outcome of Preterm Infants?.- Index
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