Contains the presentations and discussions that took place during a symposium at the CIBA Foundation on October 1-3, 1990 on the subject of catalytic antibodies. The recognition that monoclonal antibodies can possess catalytic activity is a recent advance with profound ramifications for chemistry. In addition to their potential commercial applications as catalysts for reactions, for which there are no known enzymes, antibodies promise to provide valuable insight into the detailed mechanisms of biological catalysis and organic chemistry.
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Partial table of contents:
A Catalytic Antibody Uses a Multistep Kinetic Sequence (S.
Benkovic, et al.).
Nuclear Magnetic Resonance Studies of Antibody-Antigen
Interactions (Y. Arata).
Approaches to the Design of Semisynthetic Metal-Dependent
Catalytic Antibodies (G. Nakayama & P. Schultz).
Catalytic Antibodies: Contributions from Engineering and
Expression in Escherichia coli (A. Plückthun & J.
Stadlmüller).
Screening Combinatorial Antibody Libraries for Catalytic Acyl
Transfer Reactions (L. Sastry, et al.).
Antibody Catalysis of Carbon-Carbon Bond Formation (D.
Hilvert).
Catalytic Antibodies: A New Window on Protein Chemistry (C.
Suckling, et al.).
Tritylase Antibodies (B. Iverson, et al.).
Index of Contributors.
Subject Index.
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Derek J. Chadwick and Joan Marsh are editors for Catalytic Antibodies and other scientific titles.
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