Synthetic Analgesics provides a comprehensive discussion of morphinans and 6, 7-benzomorphans. Morphinans belong to a class of compounds possessing the main structural skeleton of morphine. Chemists have attempted to modify the morphine molecule in order to obtain analgesics without side-effects and addictive properties. The book is organized into two parts. Part A discusses the chemistry and pharmacology of morphinans, covering the syntheses of analgesics with morphine-like activity, N-methyl-morphinan, 3-hydroxy-N-methyl-morphinan and analogous compounds, toxicity and analgesic action of morphinan, and morphinans with anti-morphine activity. Part B deals with the chemistry and pharmacology of 6, 7-benzomorphans; and opiate antagonists in the benzomorphan series.
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