The first chapter of Horizons in Cancer Research. Volume 72 discusses the Ewing’s sarcoma family of tumors, including classic Ewing’s sarcoma of the bone, extraskeletal Ewing’s sarcoma and malignant peripheral primitive neuroectodermal tumor of both bone and soft tissue. The following chapter discusses Primary Ewing’s sarcoma of the base of the tongue, particularly its diagnosis and treatment. Additionally, the authors examine dual proteasome and histone deacetylase6 inhibitor, dual MDM2 and histone deacetylase inhibitor, and dual bromodomain-containing protein 4 and histone deacetylase inhibitor. The authors go on to examine the genes and proteins involved in mitosis that are proposed as candidates for biomarkers in different types of cancer (colon, lung, prostate, breast and ovarian, among others). The penultimate chapter reviews the published evidence of aromatase inhibitors in breast cancer risk reduction. The recommended patient populations for the use of aromatase inhibitors, expected benefits, adverse effects and monitoring parameters are addressed. The transcription factor and chromatin structure-related aspects of cancer treatment are the focus of the final chapter.
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