Hoang Q. (the University of Texas MD Anderson Cancer Center, Houston, USA) Nguyen & Peter F. (M.D. Anderson Cancer Center, Houston, Texas, USA) Thall 
Bayesian Designs for Phase I-II Clinical Trials [EPUB ebook] 

Sokongan

Reliably optimizing a new treatment in humans is a critical first step in clinical evaluation since choosing a suboptimal dose or schedule may lead to failure in later trials. At the same time, if promising preclinical results do not translate into a real treatment advance, it is important to determine this quickly and terminate the clinical evaluation process to avoid wasting resources.

Bayesian Designs for Phase I–II Clinical Trials describes how phase I–II designs can serve as a bridge or protective barrier between preclinical studies and large confirmatory clinical trials. It illustrates many of the severe drawbacks with conventional methods used for early-phase clinical trials and presents numerous Bayesian designs for human clinical trials of new experimental treatment regimes.

Written by research leaders from the University of Texas MD Anderson Cancer Center, this book shows how Bayesian designs for early-phase clinical trials can explore, refine, and optimize new experimental treatments. It emphasizes the importance of basing decisions on both efficacy and toxicity.

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Format EPUB ● Halaman-halaman 324 ● ISBN 9781315354224 ● Penerbit CRC Press ● Diterbitkan 2017 ● Muat turun 3 kali ● Mata wang EUR ● ID 5576401 ● Salin perlindungan Adobe DRM
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