Organozinc reagents are less reactive than Grignard reagents but they are much more chemoselective. Since the Negishi cross-coupling reaction developed by Ei-ichi Negishi, who was awarded the Nobel Price in chemistry in 2010, a number of cross-coupling reactions involving organozinc derivatives and transition metal catalysts (Pd, Ni, Fe, Co, Cu, …) has been tuned up to form C-C bonds. This book on ‘Organozinc derivatives and transition metal catalysts’ has been written by experts in the field and is a complement to the book entitled ‘Grignard reagents and transition metal catalysts’ (a De Gruyter book, edited by J. Cossy).
Grignard reagents or organozinc reagents, that is the question? From a given substrate, what is the best organometallic reagent and the best transition metal to form a C-C bond by using a cross-coupling reaction? The solution might be found in these two books.
Mengenai Pengarang
Janine Cossy
is Professor of Organic Chemistry at the ESPCI Paris since 1990. Her research interests focus on the synthesis of natural products and/or biologically active compounds as well as on the development of synthetic methods.
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