A compilation of recent advances and applications in asymmetric
catalysis
The field of asymmetric catalysis has grown rapidly and plays a key
role in drug discovery and pharmaceuticals. New Frontiers in
Asymmetric Catalysis gives readers a fundamental understanding of
the concepts and applications of asymmetric catalysis reactions and
discusses the latest developments and findings. With contributions
from preeminent scientists in their respective fields, it
covers:
* ‘Rational’ ligand design, which is critically dependent on the
reaction type (reduction, oxidation, and C-C bond formation)
* Recent findings on activation of C-H bonds, C-C bonds, and small
molecules (C=O, HCN, RN=C, and CO2) and the latest developments on
C-C bond reorganization, such as metathesis
* Advances in ‘chirally economical’ non-linear phenomena, racemic
catalysis, and autocatalysis
* Some of the recent discoveries that have led to a renaissance in
the field of organocatalysis, including the development of chiral
Brönstead acids and Lewis acidic metals bearing the conjugate
base of the Brönstead acids as the ligands and the chiral
bi-functional acid/base catalysts
The book ends with a thought-provoking perspective on the future of
asymmetric catalysis that addresses both the challenges and the
unlimited potential in this burgeoning field. This is an
authoritative, up-to-date reference for organic chemists in
academia, government, and industries, including pharmaceuticals,
biotech, fine chemicals, polymers, and agriculture. It is also an
excellent textbook for graduate students studying advanced organic
chemistry or chemical synthesis.
Jadual kandungan
Introductory Preface (K. Mikami and M. Lautens).
Chapter 1. Ligand Design for Catalytic Asymmetric Reduction (T. Ohkuma, M. Kitamura, and R. Noyori).
Chapter 2. Ligand Design for Oxidation (T. Yamada)
Chapter 3. Ligand Design for C-C Bond Formation (R. Shintani and T. Hayashi).
Chapter 4. Activation of small molecules (C=O, HCN, RN=C, and CO2) (K. Nozaki).
Chapter 5. Asymmetric Synthesis Based on the Catalytic Activation of C-H and C-C Bonds (C.-J. Li).
Chapter 6. Recent Progress in the Metathesis Reaction M. Mori).
Chapter 7. Activation and De-activation (K. Mikami and K. Aikawa).
Chapter 8. Auto-Catalysis (K. Soai).
Chapter 9. Recent Advances in Catalytic Asymmetric Desymmetrization Reactions (T. Rovis).
Chapter 10. History & Perspective of Chiral Organic Catalysts (G.Lelais and D.W.C.Macmillan).
Chapter 11. Chiral Acid Catalysts (K. Ishihara and H. Yamamoto).
Chapter 12. Recent Advances in Chiral Base Catalysts (M. Shibasaki and Motomu Kanai).
Future perspective (K. Mikami and M. Lautens).
Mengenai Pengarang
Koichi Mikami is Professor in the Department of Applied
Chemistry at the Tokyo Institute of Technology.
Mark Lautens is Astra Zeneca Professor of Organic
Synthesis and Merck Frosst/NSERC Industrial Research Chair in the
Davenport Laboratories at the University of Toronto.
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