* Provides a comprehensive update on therapies for
Parkinson’s disease and other movement disorders
* Describes the basic mechanisms of neurodegeneration,
pharmacologic interventions for motor and non-motor symptoms, and
surgical management
* Features summary tables and algorithms that serve as a quick
reference guide for practical treatment decisions
* The expert guidance of recognised authorities will enable
readers of this book to plan their patients’ care with
greater confidence
Jadual kandungan
Preface ix
Contributors xi
Part I Parkinson’s Disease and Parkinsonism
1 The Etiopathogenesis of Parkinson’s Disease: Basic Mechanisms of Neurodegeneration 3
C. Warren Olanow and Kevin Mc Naught
2 Physiology of Parkinson’s Disease 25
Shlomo Elias, Zvi Israel and Hagai Bergman
3 Pharmacology of Parkinson’s Disease 37
Jonathan M. Brotchie
4 The Treatment of Early Parkinson’s Disease 49
Olivier Rascol and Regina Katzenschlager
5 Treatment of Motor Complications in Advanced Parkinson’s Disease 71
Susan H. Fox and Anthony E. Lang
6 Managing the Non-Motor Symptoms of Parkinson’s Disease 91
Werner Poewe and Klaus Seppi
7 Surgery for Parkinson’s Disease 121
Jens Volkmann
8 Future Cell- and Gene-Based Therapies for Parkinson’s Disease 145
Tomas Björklund, Asuka Morizane, Deniz Kirik and Patrik Brundin
9 Parkinson-Plus Disorders 157
Martin Köllensperger and Gregor K. Wenning
Part II Tremor Disorders
10 Essential Tremor 179
Rodger J. Elble
11 Other Tremor Disorders 193
Günther Deuschl
Part III Dystonia, Cramps, and Spasms
12 Pathophysiology of Dystonia 205
Mark Hallett
13 General Management Approach to Dystonia 217
Cynthia L. Comella
14 Botulinum Toxin for Treatment of Dystonia 227
Dirk Dressler
15 Surgical Treatments of Dystonia 241
Christopher Kenney and Joseph Jankovic
16 Wilson’s Disease 251
George J. Brewer
17 Cramps and Spasms 263
Christine D. Esper, Pratibha G. Aia, Leslie J. Cloud and Stewart A. Factor
18 Stiff Person Syndrome 283
Philip D. Thompson and Hans-Michael Meinck
Part IV Chorea, Tics and other Movement Disorders
19 Huntington’s Disease 295
Kevin M. Biglan and Ira Shoulson
20 Chorea 317
Francisco Cardoso
21 Treatment of Tics and Tourette Syndrome 331
Harvey S. Singer and Erika L.F. Hedderick
22 Therapeutics of Paroxysmal Dyskinesias 345
Shyamal H. Mehta and Kapil D. Sethi
23 Treatment of Miscellaneous Disorders 353
Marie Vidailhet, Emmanuel Roze and David Grabli
24 Myoclonus 363
Shu-Ching Hu, Steven J. Frucht and Hiroshi Shibasaki
Part V Drug-induced Movement Disorders
25 Neuroleptic-Induced Movement Disorders 373
S. Elizabeth Zauber and Christopher G. Goetz
26 Other Drug-Induced Dyskinesias 389
Oscar S. Gershanik
Part VI Ataxia and Disorders of Gait and Balance
27 Ataxia 407
Thomas Klockgether
28 Treatment of Gait and Balance Disorders 417
Bastiaan R. Bloem, Alexander C. Geurts, S. Hassin-Baer and Nir Giladi
Part VII Restless Legs Syndrome
29 The Restless Legs Syndrome 447
Richard P. Allen and Birgit HEURogl
Part VIII Pediatric Movement Disorders
30 Pediatric Movement Disorders 471
Jonathan W. Mink
Part IX Psychogenic Movement Disorders
31 Psychogenic Movement Disorders 479
Elizabeth Peckham and Mark Hallett
Index 489
Mengenai Pengarang
Mark Hallett, MD, Senior Investigator at National Institute of Neurological Disorders and Stroke (NINDS), Chief of the Medical Neurology Branch and Chief of Human Motor Control Section; Editor-in-Chief of Clinical Neurophysiology; Associate Editor of Brain.
Werner Poewe, Chairman of the Department of Neurology at Medical University of Innsbruck; Editorial board member of Movement Disorder, Journal of Neurology, Journal of Neural Transmission, and Aktuelle Neurologie.
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