The first comprehensive book focusing on synthesis and applications of macrocyclic polyamines and their derivatives
Macrocyclic polyamines are a class of widely used important compounds. This is the first book that systematically summarizes the synthesis and applications of macrocyclic polyamines and their analogues, including the properties and synthetic methods of macrocyclic polyamines, chemical nucleases based on macrocyclic polyamines, the derivatives of macrocyclic polyamines as nano-vector materials, macrocyclic polyamines derivatives for bio-imaging, chemical sensors based on macrocyclic polyamines, and other applications of macrocyclic polyamines.
Macrocyclic Polyamines: Synthesis and Applications includes most of the studies involving macrocyclic polyamines and their derivatives, and may be used as a reference for the researchers in related fields. It offers in-depth coverage of cyclization modes; special procedures for tetraza macrocyclic compounds; diacids-diamines condensation; oxidative DNA cleaving by macrocyclic polyamines; lipids with cationic MPA headgroups; the derivatives of DOTA, DO3A, and PCTA; receptors for anions; sensors for bioactive molecules; macrocyclic polyamines for solvent extraction and membrane transport of amino acids and their derivatives, electrophoretic separation, and open-tubular CEC; and much more.
?The first book that systematically summarizes the chemistry of macrocyclic polyamines and their derivatives in terms of synthetic methods for their preparation, functionalization, and application in the main fields of chemical sensors, chemical nucleases, drug-delivery, bio-imaging and vector materials
?Provides a comprehensive reference for the researchers working on macrocyclic polyamines
?Offers train of thought in related research fields such as organic chemistry, coordination chemistry, analytical chemistry, supramolecular chemistry, biomaterials, etc.
Macrocyclic Polyamines: Synthesis and Applications will not only provide a reference for the researchers working on macrocyclic polyamines, but also offer opportunities for researchers in related research fields to understand the benefits of these key compounds.
Jadual kandungan
Preface ix
1 Introduction 1
1.1 Classification of Macrocyclic Polyamines 1
1.1.1 Aliphatic Macrocyclic Polyamines 1
1.1.2 Aromatic-Containing Macrocyclic Polyamines 1
1.1.3 Macrocyclic Polyimines 2
1.1.4 Macrocyclic Polyamides 2
1.1.5 Cryptands 2
1.2 Properties of Macrocyclic Polyamines 3
1.2.1 Acid–Base Properties 3
1.2.2 Coordination Property 3
1.3 Applications of Macrocyclic Polyamines 4
References 5
2 Synthetic Methods for Macrocyclic Polyamines 7
2.1 Ring-Closure Modes 7
2.1.1 Intramolecular Cyclization 7
2.1.2 1 + 1 Cyclization 7
2.1.3 2 + 2 Cyclization 8
2.1.4 Other Cyclization Modes 8
2.2 The Synthesis of Saturated Macrocyclic Polyamines 9
2.2.1 Ring Closure Using Sulfonamides 9
2.2.2 The Removal of Tosyl Protecting Groups 11
2.2.3 The Use of Easily Removable Protecting Groups 12
2.2.4 Special Procedures for Tetraaza Macrocyclic Compounds 13
2.3 Aromatic Subunit-Containing Polyazamacrocycles 14
2.3.1 Alkylation of Sulfonamide Salts with Dihalomethyl Arenes 15
2.3.2 Metal-Catalyzed N-arylation 16
2.4 Macrocyclic Polyimines (Schiff Bases) 18
2.4.1 Metal Template Reactions 18
2.4.1.1 Macrocyclic Schiff Bases without Aromatic Units 20
2.4.1.2 Macrocyclic Schiff Bases Containing Aromatic Units 21
2.4.2 Template-Free Cyclization 22
2.4.2.1 Condensation of Carbonyls with Aliphatic Diamines 23
2.4.2.2 Condensation of Carbonyls with Aromatic Diamines 25
2.5 Macrocyclic Amides 26
2.5.1 The Crab-Like Cyclization 26
2.5.2 Diacid-Diamine Condensation 29
2.6 Cryptands 33
2.6.1 Coupling of the Preformed Macrocycles 33
2.6.2 Direct Organic Synthesis 35
2.6.3 Spherical Cryptands 37
References 39
3 Chemical Nucleases Based on Macrocyclic Polyamines 45
3.1 Hydrolysis of Nucleic Acids 45
3.1.1 Metal Complexes of Macrocyclic Ligands 46
3.1.1.1 Lanthanide(III) Complexes 48
3.1.1.2 Transition Metal Complexes of Macrocyclic Ligands 51
3.1.1.3 Metal Complex–DNA Binder Conjugates 64
3.1.2 Metal-Free Macrocyclic Polyamines 67
3.2 Oxidative Cleavage of Nucleic Acids 70
3.2.1 Oxidative DNA Cleavage by Macrocyclic Polyamine Metallic Complexes 70
3.2.2 Oxidative DNA Cleavage by Metal-Free Macrocyclic Polyamines 74
3.3 Summary 76
References 76
4 Derivatives of Macrocyclic Polyamines as Nanovector Materials 83
4.1 Derivatives of MPAs as Nonviral Gene Vectors 83
4.1.1 Cationic Polymers 85
4.1.2 Lipids with Cationic MPA Headgroups 90
4.1.2.1 TACN-Based Lipids 91
4.1.2.2 Cyclen-Based Lipids 93
4.1.3 Other Types of Vectors 99
4.2 Multifunctional Materials for Both Drug Delivery and
Bio-Imaging 100
4.2.1 Gd Complexes 100
4.2.2 64Cu Complexes 103
4.2.3 Miscellaneous 104
4.3 Summary 104
References 105
5 Macrocyclic Polyamine Derivatives for Bio-Imaging 109
5.1 Typical Macrocyclic Polyamines for Magnetic Resonance Imaging (MRI) 111
5.1.1 DOTA and Its Derivatives 111
5.1.2 DO3A and Its Derivatives 118
5.1.3 PCTA and Its Derivatives 124
5.1.4 TETA and NOTA 126
5.2 Other Derivatives of Macrocyclic Polyamines for MRI 128
5.2.1 Phosphonate Macrocyclic Ligands 128
5.2.2 Ligands with Multiamide Arms 129
5.2.3 Ligands with Multihydroxy Arms 130
5.2.4 Other Types 131
5.3 MPAs for PET Imaging 133
References 135
6 Chemical Sensors Based on Macrocyclic Polyamines 141
6.1 Sensors for Metal Cations 141
6.1.1 Zn(II) and Cd(II) 141
6.1.2 Cu(II) and Pb(II) 147
6.1.3 Hg(II), Ag(I), and Others 149
6.2 Receptors for Anions 153
6.2.1 Phosphonates 153
6.2.2 Amino Acids 156
6.2.3 Other Anions 159
6.3 p H Indicator 162
6.4 Sensors for Bioactive Molecules 164
6.4.1 Small Molecules and Nucleotide 164
6.4.2 Proteins 169
6.4.3 Others 169
6.5 Summary 172
References 173
7 Other Applications of Macrocyclic Polyamines 177
7.1 Macrocyclic Polyamines as Ionophores 177
7.1.1 Macrocyclic Polyamines for Solvent Extraction and Membrane Transport of Metal Cations 177
7.1.2 Macrocyclic Polyamines for Solvent Extraction and Membrane Transport of Amino Acids and Their Derivatives 185
7.2 Macrocyclic Polyamines for Electrophoretic Separation 190
7.2.1 Macrocyclic Polyamines as Additives for Running Solution 191
7.2.2 Macrocyclic Polyamines for Open-Tubular CEC 193
7.2.3 Macrocyclic Polyamines as the Bonded Phase for Monolithic Columns 204
References 206
Index 209
Mengenai Pengarang
Xiaoqi Yu, Ph D, is Changjiang Chair professor and Dean of College of Chemistry, Sichuan University. He has received several awards, including The National Science Fund for Distinguished Young Scholars of China (2007). His research interests include biomedical materials chemistry (especially for non-viral gene and drug delivery vectors) and methodology of organic syntheses.
Ji Zhang, Ph D is a professor in College of Chemistry, Sichuan University, China. His research focuses on nano-biomaterials, i.e. design, synthesis and establishment of novel non-viral gene and drug delivery systems and relative structure-activity relationship studies.
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