The purpose of this monograph is to present readers with a comprehensive and cutting edge description of neurochemical effects of diet (beneficial and harmful effects) in normal human brain and to discuss how present day diet promotes pathogenesis of stroke, AD, PD, and depression in a manner that is useful not only to students and teachers but also to researchers, dietitians, nutritionists and physicians. A diet in sufficient amount and appropriate macronutrients is essential for optimal health of human body tissues. In brain, over-nutrition, particularly with high-calorie diet, not only alters cellular homeostasis, but also results in changes in the intensity of signal transduction processes in reward centers of the brain resulting in food addiction. Over-nutrition produces detrimental effects on human health in general and brain health in particular because it chronically increases the systemic and brain inflammation and oxidative stress along with induction of insulin resistance and leptin resistance in the brain as well as visceral organs. Onset of chronic inflammation and oxidative stress not only leads to obesity and heart disease, but also promotes type II diabetes and metabolic syndrome, which are risk factors for both acute neural trauma (stroke) and chronic age-related neurodegenerative and neuropsychological disorders, such as Alzheimer disease (AD), Parkinson disease (PD) and depression.
Inhoudsopgave
Preface.- Effect of long term consumption of high calorie diet, low calorie diet and Mediterranean diet on human metabolism.- Neurochemical effects of long term consumption of high fat contents in the diet.- Neurochemical effects of long term consumption of high simple carbohydrate contents in the diet.- Neurochemical effects of long term consumption of high animal protein contents in the diet.- Biochemical effects of soft drinks consumption in the brain.- Biochemical effects of high salt consumption in the brain.- Roles of fiber in the diet and its effects on metabolic processes in the brain.- Effects of the high calorie diet on the development of chronic visceral diseases.- Effects of high calorie diet on the development of neurological disorders.- Modifications of high calorie diet needed for optimal health of human brain.- Summary, perspective and directions for future research.- Index.
Over de auteur
Akhlaq A. Farooqui is a leader in the field of signal transduction processes, lipid mediators, phospholipases A2, glutamate neurotoxicity, phytochemicals and human health and neurological disorders. He has published cutting edge research on the role of phospholipases A2 in signal transduction processes, generation and identification of lipid mediators during neurodegeneration by lipidomics and has studied the involvement of glycerophospholipid, sphingolipid- and cholesterol-derived lipid mediators in kainic acid neurotoxicity, an experimental model of neurodegenerative diseases.
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