The first and only book devoted entirely to MEMBRANE LIPID
ASYMMETRY AND ITS BIOLOGICAL IMPLICATIONS
Transmembrane Dynamics of Lipids is comprised of contributions
from expert authors from leading research groups that present
up-to-date quantitative data on the formation, stability, and
biological consequences of the asymmetrical organization of lipids
in cell membranes.
Incorporating an impressive amount of new, previously
uncollected data, the book examines transmembrane asymmetry and
movement of lipids in biological membranes, and methods for the
measurement of transmembrane lipid motion, emphasizing the role of
lipid flippases and discusses biological functions associated with
lipid asymmetry. In addition, it draws attention to important new
discoveries in the field, such as the correlation between
malfunction of lipid flippases and human diseases such as
thrombosis and cancer. The book also addresses the manifold methods
that are used to measure the rate of transmembrane movement of
lipids in biological and model systems.
The only guide to new discoveries regarding lipids in cell
membranes, Transmembrane Dynamics of Lipids is designed to appeal
to biophysicists, biochemists, and cellular and molecular
biologists working in the growing field of membrane research.
Inhoudsopgave
Introduction
List of Contributors.
Part I: ASSESSING TRANSMEMBRANE MOVEMENT AND ASYMMETRY OF
LIPIDS.
1. Methods for the Determination of Lipid Transmembrane
Distribution and Movement in Biological Membranes (Philippe F.
Devaux and Andreas Herrmann).
2. Detection and Measurement of Unlabeled Lipid Transmembrane
Movement(Iván López-Montero, Marisela Vélez and
Philippe F. Devaux).
Part II: LIPID ASYMMETRY IN CELL MEMBRANES.
3. New Insights in Membrane Lipid Asymmetry in Animal and Plant
Cells (Alain Zachowski).
4. Sphingolipid Asymmetry and Transmembrane Translocation in
Mammalian Cells (Gerrit van Meer, Sylvia Neumann, and Per
Haberkant).
5. Transbilayer Movement and Distribution of Cholesterol
(Peter Müller, Anna Pia Plazzo, and Andreas
Herrmann).
Part III. ENERGY-INDEPENDENT PROTEIN-MEDIATED TRANSMEMBRANE
MOVEMENT OF LIPIDS.
6. Phospholipid Flip-Flop in Biogenic Membranes (Anant K.
Menon and Andreas Herrmann).
7. Phospholipid Scramblase: When Phospholipid Asymmetry Goes
Away (Edouard M. Bevers and Patrick L. Williamson).
Part IV: ENERGY-DEPENDENT LIPID TRANSPORT ACROSS
MEMBRANES.
8. Flip or Flop: Mechanism and (Patho)Physiology of
P4-ATPase-Catalyzed Lipid Transport (Patricia M.
Verhulst, Joost C.M. Holthuis, and Thomas G. Pomorski).
9. Coupling Drs2p to Phospholipid Translocation, Membrane
Asymmetry, and Vesicle Budding (Xiaoming Zhou, Paramasivam
Natarajan, Baby-Periyanayaki Muthusamy, Todd R. Graham, and Ke
Liu).
10. Substrate Specifi city of the Aminophospholipid Flippase
(Shelley M. Cook and David L. Daleke).
11. The Flippase Delusion? (Naomi L. Pollock, Petra H.M.
Niesten, and Richard Callaghan).
Part V: RELEVANCE OF LIPID TRANSMEMBRANE DISTRIBUTION
FOR MEMBRANE PROPERTIES AND PROCESSES
12. Membrane Lipid Asymmetry and Permeability to Drugs: A Matter
of Size (Adam Blanchard and Cyril Rauch).
13. Endocytosis and Lipid Asymmetry (Nina Ohlwein, Andreas
Herrmann, and Philippe F. Devaux).
Part VI: APOPTOSIS AND DISEASES: CONSEQUENCES OF DISRUPTION
TO LIPID TRANSMEMBRANE ASYMMETRY
14. Membrane Lipid Asymmetry in Aging and Apoptosis
(Krishnakumar Balasubramanian and Alan J. Schroit).
15. Phosphatidylserine Exposure in Hemoglobinopathies (Frans
A. Kuypers and Eric Soupene).
16. Scott Syndrome: More Than a Hereditary Defect of Plasma
Membrane Remodeling (Florence Toti and Jean-Marie
Freyssinet).
17. ABCA1, Tangier Disease, and Lipid Flopping (Ana Zarubica
and Giovanna Chimini).
Over de auteur
Philippe F. Devaux, Ph D, is Professor of Physics at the Paris 7
University.He has long-standing expertise in teaching molecular and
cellular biophysics and physics applied to biology and medicine. He
is the author of almost two hundred scientific papers and three
books, and is an Editor of the European Biophysics Journal.
Andreas Herrmann, Ph D, is Professor of Molecular Biophysics at
Humboldt-University of Berlin. He teaches courses on the subjects
of molecular; cell; and membrane biophysics, optical spectroscopy,
and fluorescence microscopy. He is the author of more than two
hundred scientific papers focusing on lipid dynamics in biological
membranes and molecular mechanisms of virus infection.
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