Gene expression studies have revealed diagnostic profiles and upregulation of specific pathways in many solid tumors. The explosion of new information in gene expression profiling could potentially lead to the development of tailored treatments in many solid tumors. In addition many studies are ongoing to validate these signatures also in predicting response to hormonal, chemotherapeutic and targeted agents in breast cancer as well as in other tumors.
Diagnostic, Prognostic and Therapeutic Value of Gene Signatures provides readers a useful and comprehensive resource about the range of applications of microarray technology in oncological diseases. Topics covered include gene signatures and soft tissue sarcomas, prognostic relevance of breast cancer signatures, gene expression profiling of colorectal cancer and liver metastasis, gene signatures in GISTs, CNVs and gene expression profiles in pancreatic cancer, and gene signatures in head/neck, lung and gastric tumors.
Diagnostic, Prognostic and Therapeutic Value of Gene Signatures will be of great value to residents and fellows, physicians, pathologists and medical oncologists.
Inhoudsopgave
Preface.- Gene signatures and soft tissue sarcomas: status of art and perspectives.- Heterogeneity of breast cancer: gene signatures and beyond.- Gene signatures in CRC and liver metastasis.- Gene signatures in Gastrointestinal Stomal Tumors (GIST).- Pancreatic Cancer Genetics.- Diagnostic, prognostic and therapeutic value of gene signatures in non-small-cell lung cancer.- Gene signatures in Gastric Cancer.- Gene signatures in Colorectal Cancer.- The role of epigenetics in cancer: from molecular function to high-throughput assays.- Primary Epithelial Ovarian Neoplasms: New concepts concerning origin, pathogenesis and classification based on morphology, immunomarkers, molecular features and gene expression studies.- Thyroid carcinoma: molecular signature by histotype specific mutations and gene expression patterns.
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