In this fast moving field the main goal of this volume is to provide up-to-date information on the molecular and functional properties and pharmacology of mammalian TRP channels. Leading experts in the field describe properties of a single TRP protein/channel or portray more general principles of TRP function and important pathological situations linked to mutations of TRP genes or their altered expression. Thereby this volume on Transient Receptor Potential (TRP) Channels provides valuable information for readers with different expectations and backgrounds, for those who are approaching this field of research as well as for those wanting to make a trip to TRPs.
Inhoudsopgave
TRPs as Special Cell Sensors: Temperature Sensing with TRPs.- TRPs in Mechano-sensing and Volume Regulation.- TRPs as Chemosensors (ROS, RNS, RCS, Gasotransmitters).- Photosensitive TRPs.- TRPs in Taste and Chemesthesis.- Pain.- TRPs in Hearing.- TRPs in Olfaction.- TRP Structure.- Pain.- TRPs in Hearing.- TRP in Olfaction.- General Topics: Evolutionary Conserved, Multitasking TRP Channels-lessons From Worms and Flies.- TRPs as Novel Drug Targets.- TRPs in Endocrinology.- TRPs Modulation by Toxins.- TRPs and Phosphoinositides.- TRPs Modulation by Natural Compounds.- What do we Really Know and What do we Need to Know: Controversies, Perspectives, Surprises.
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