This timely and topical book reviews the important developments in the ‘B12-field’ with regard to biological, chemical, pharmaceutical and medicinal aspects.
In over 30 chapters the approx. 100 internationally renowned authors give deeper insight into the prospering research activites around B12. This book is a must for everybody who works with or on vitamins and porphyrine (-like) ring systems.
Topics of particular interest include: Biosynthesis of Vitamin B12; B12-catalyzed enzymatic reactions and their mechanisms; structural B12-chemistry; reactivity of B12 and B12-models; structure and function of B12-proteins; metabolic transport and storage of B12; pathological effects of B12-deficiency.
Inhoudsopgave
NEW STRUCTURAL AND BIOSYNTHETIC ASPECTS OF THE UNUSUAL CORE-LIPIDS FROM ARCHAEBACTERIAE
Cobalamin biochemistry
B 12-biosynthesis in an aerobic organism
A mechanistic overview of B 12-dependent processes
Insight into the mechanism of B 12-dependent enzymes
Some mechanistic aspects of coenzyme B 12-dependent rearrangements
Model studies for the methylmalonyl-succinyl rearrangement
High resolution crystal structures of cobalamins
Cobalamin binding proteins
DISCOVERY OF A BIOLOGICAL ORGANOMETALLIC REACTION SEQUENCE INVOLVING VITAMIN B 12
Recent investigations on the biosynthesis of the 5, 6-dimenthylbenzimidazole moiety of vitamin B 12; Coenzyme B 12-dependent enzymes and their models
VITAMIN B 12 BIOSYNTHESIS
How nature synthesizes Ba 12 without oxygen
B 12 pathway study in Pseudomonas denitrificans
Recent structure-function studies of B 12 coenzymes
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