This report is a congressionally mandated review of the US Department of Agriculture’s Research, Education, and Economics (REE) mission area, the main engine of publicly funded agricultural research in the United States. A changing social and scientific context of agriculture requires a new vision of agricultural researchone that will support agriculture as a positive economic, social, and environmental force. REE is uniquely positioned to advance new research frontiers in environment, public health, and rural communities. The report recommends that REE be more anticipatory and strategic in its use of limited resources and guide and champion new directions in research.