The six-volume set LNCS 11764, 11765, 11766, 11767, 11768, and 11769 constitutes the refereed proceedings of the 22nd International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2019, held in Shenzhen, China, in October 2019.The 539 revised full papers presented were carefully reviewed and selected from 1730 submissions in a double-blind review process. The papers are organized in the following topical sections: Part I: optical imaging; endoscopy; microscopy.Part II: image segmentation; image registration; cardiovascular imaging; growth, development, atrophy and progression.Part III: neuroimage reconstruction and synthesis; neuroimage segmentation; diffusion weighted magnetic resonance imaging; functional neuroimaging (f MRI); miscellaneous neuroimaging.Part IV: shape; prediction; detection and localization; machine learning; computer-aided diagnosis; image reconstruction and synthesis.Part V: computer assisted interventions; MIC meets CAI.Part VI: computed tomography; X-ray imaging.