Attention deficit hyperactivity disorder (ADHD) is a common neurobehavioral disorder affecting 5–10% of children and adolescents and 3% of adults. Attention Deficit Hyperactivity Disorder: From Genes to Patients aims to provide a comp- hensive, state-of-the-art overview of the critical aspects of ADHD, and hopefully will serve as a quick and up-to-date reference source for professionals with an int- est in ADHD. The book is divided into three major areas that follow an historical survey. The first group of chapters deals with current theories on the pathophysiology of ADHD, and focuses on neurotransmitters and the contributions and validity of animal m- els. The second section emphasizes the evaluation and treatment of patients with ADHD, from the day-to-day approach by the clinical psychologist to the more sophisticated anatomical and functional imaging strategies that have emerged in the last decade. In addition, chapters dealing with specific impairments, such as those pertaining to reading, social interaction, and working memory, are also included for more detailed analysis of these important aspects and their respective contributions to global functioning. The third and final section provides an expanded review on the pharmacotherapy of ADHD and the appropriate methods for selection of specific drugs for individual patients based on drug kinetics and gene expression. David Gozal, MD Dennis L. Molfese, Ph D vii CONTENTS Dedication . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . v Preface. . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . vii Contributors. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . xi 1 Historical Aspects of Attention Deficit Hyperactivity Disorder . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Roscoe A. Dykman 2 Scanning the Genome for Attention Deficit Hyperactivity Disorder . . . . . . . . . . . . . . . . . . . . . . . . .
Inhoudsopgave
Historical Aspects of Attention Deficit Hyperactivity Disorder.- Scanning the Genome for Attention Deficit Hyperactivity Disorder.- Dopamine Knockouts and Behavior.- The Spontaneously Hypertensive Rat as a Model of Attention Deficit Hyperactivity Disorder.- The Roles of Norepinephrine and Serotonin in Attention Deficit Hyperactivity Disorder.- Intermittent Hypoxia During Sleep as a Model of Environmental (Nongenetic) Contributions to Attention Deficit Hyperactivity Disorder.- The Psychological Evaluation of Attention Deficit Hyperactivity Disorder in School-Aged Children.- Executive Function.- The Neuropsychology of Attention Deficit Hyperactivity Disorder.- Attention Deficit Hyperactivity Disorder and Learning Disabilities.- Selective Attention Deficits in Children with Attention Deficit Hyperactivity Disorder.- Working Memory in Children with ADHD.- Developmental Underpinnings of the Association of Attention Deficit Hyperactivity Disorder and Its Subtypes to Neuropsychological and Academic Weaknesses.- Social Functioning of Children With Attention Deficit Hyperactivity Disorder.- Reading Disabilities in Children With Attention Deficit Hyperactivity Disorder.- Attention Deficit Hyperactivity Disorder and the Brain.- Anatomical and Functional Neuroimaging Studies of Children and Adolescents With Attention Deficit Hyperactivity Disorder.- State Regulation and Attention Deficit Hyperactivity Disorder.- Sleep and Attention Deficit Hyperactivity Disorder.- Neuropsychological Performance in Adults With Attention Deficit Hyperactivity Disorder.- Psychostimulants in Attention Deficit Hyperactivity Disorder.- Pharmacokinetic and Pharmacodynamic Drug Interactions.
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