ATP, the intracellular energy source, is also an extremely
important cell-cell signalling molecule for a wide variety of
cells across evolutionarily diverse organisms. The extracellular
biochemistry of ATP and its derivatives is complex, and the
multiple membrane receptors that it activates are linked to many
intracellular signalling systems.
Purinergic signalling affects a diverse range of cellular
phenomena, including ion channel function, cytoskeletal dynamics,
gene expression, secretion, cell proliferation, differentiation and
cell death. Recently, this class of signalling molecules and
receptors has been found to mediate communication between neurons
and non-neuronal cells (glia) in the central and peripheral nervous
systems. Glia are critical for normal brain function, development
and response to injury. Neural impulse activity is detected by glia
and purinergic signalling is emerging as a major means of
integrating functional activity between neurons, glia and vascular
cells in the nervous system. These interactions mediate effects of
neural activity on the development of the nervous system and in
association with injury, neurodegeneration, myelination and
cancer.
Bringing together contributions from experts in diverse fields,
including glial biologists, neurobiologists and specialists in
purinergic receptor structure and pharmacology, this book considers
how extracellular ATP acts to integrate communication between
different types of glia, and between neurons and glia.
Beginning with an overview of glia and purinergic signalling, it
contains detailed coverage of purine release, receptors and
reagents, purinergic signalling in the neural control of glial
development, glial involvement in information processing, and
discussion of the interactions between neurons and microglia.
Inhoudsopgave
Symposium on Purinergic signalling in neuron-glia
interactions, held at the Novartis Foundation, London,
7-9 June 2005.
Editors: Derek J. Chadwick (Organizer) and Jamie
Goode.
This symposium was based on a proposal made by R. Douglas
Fields.
R. Douglas Fields Chair’s introduction.
Kristjan R. Jessen A brief look at glial cells.
Bernard Zalc The acquisition of myelin: a success
story.
Discussion.
Geoffrey Burnstock Purinergic signalling–an
overview.
Discussion.
General discussion I.
Kenneth A. Jacobson, Stefano Costanzi, Bhalchandra V.
Joshi, Pedro Besada, Dae Hong Shin, Hyojin Ko, Andrei
Ivanov and Liaman Mamedova Agonists and antagonists for
P2 receptors.
Discussion.
Eduardo Lazarowski Regulated release of nucleotides and
UDP sugars from astrocytoma cells.
Discussion.
Maria P. Abbracchio and Claudia Verderio
Pathophysiological roles of P2 receptors in glial cells.
Discussion.
General discussion II.
Herbert Zimmermann ectonucleotidases in the nervous
system.
Discussion.
Joseph T. Neary, Yuan Kang, You-fang Shi, Minh D. Tran
and Ina B. Wanner P2 receptor signalling, proliferation of
astrocytes, and expression of molecules involved in cell-cell
interactions.
Discussion.
R. Douglas Fields nerve impulses regulate myelination
through purinergic signalling.
Discussion.
Beth Stevens Cross-talk between growth factor and
purinergic signalling regulates Schwann cell proliferation.
Discussion.
Freddy Jeanneteau and Moses V. Chao Promoting
neurotrophic effects by GPCR ligands.
Discussion.
Eric A. Newman A purinergic dialogue between glia and
neurons in the retina.
Discussion.
Tommaso Fellin, Jai-Yoon Sul, Marcello D’Ascenzo,
Hajime Takano, Olivier Pascual and Philip G.
Haydon Bidirectional astrocyte-neuron communication: the
many roles of glutamate and ATP.
Discussion.
Keith J. Todd and Richard Robitaille
neuron-glia interactions at the neuromuscular synapse.
Discussion.
General discussion III.
Stéphane H.R. Oliet, Aude Panatier and Richard
Piet Functional neuronal-glial anatomical remodelling in
the hypothalamus.
Discussion.
Francesco Di Virgilio Purinergic signalling between axons
and microglia.
Discussion.
Kazuhide Inoue ATP receptors of microglia involved in
pain.
Discussion.
Final discussion.
Index of contributors.
Subject index.
Over de auteur
The Novartis Foundation is an international scientific and educational charity which promotes the study and general knowledge of science and in particular encourages international co-operation in scientific research.
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