This title reflects the exponential growth in the knowledge and information on this subject and defines the extensive clinical translation of cardiovascular genetics and genomics in clinical practice. This concise, clinically oriented text is targeted at a broad range of clinicians who manage patients and families with a wide range of heterogeneous inherited cardiovascular conditions.
Cardiovascular Genetics and Genomics: Principles and Clinical Practice includes a concise and clear account on selected topics written by a team of leading experts on clinical cardiovascular genetics. Each chapter include key information to assist the clinician and case histories have been incorporated to reflect contemporary practice in clinical cardiovascular genetics and genomics. Therefore this will be of key importance to all professionals working in the discipline, from clinicians and trainees in cardiology, cardiac surgery, electrophysiology, immunology through geneticists, nursing staff and those involved in precision medicine.
Inhoudsopgave
Introduction to Genes, Genome and Inheritance.- Elements of Clinical Cardiovascular Genetics: Spectrum and Classification.- Principles and Practice of Genetic Counselling for Inherited Cardiac Conditions.- Genetic and Genomic Technologies: Next Generation Sequencing for Inherited Cardiovascular Conditions.- Pharmacogenetics and pharmacogenomics in cardiovascular medicine and surgery.- Congenital Cardiovascular Disorders including Adult Congenital Heart Disease.- Inherited cardiovascular metabolic disorders.- Mitochondrial cardiovascular diseases.- Inherited Cardiac Muscle Disorders: Hypertrophic and Restrictive Cardiomyopathies.- Inherited Cardiac Muscle Disorders: Dilated Cardiomyopathy.- Inherited Cardiac Muscle Disorders: Arrhythmogenic Right Ventricular Cardiomyopathy.- Inherited Cardiac Muscle Disorders: Left Ventricular Noncompaction.- Inherited arrhythmias: LQTS/SQTS/CPVT.- Inherited arrhythmias: Brugada syndrome and early repolarisation syndrome.- Inherited Conduction Disease and Atrial Fibrillation.- Cardiovascular manifestations in Duchenne/Becker muscular dystrophy and other primary myopathies.- Inherited cardiac amyloidosis.- Cardiovascular manifestations of inherited myotonias.- Marfan syndrome and related inherited aortopathies.- Cardiovascular manifestations in inherited connective tissue disorders.- Thoracic aortic dilatation, aneurysm and dissection.- Genetics and genomics of coronary artery disease.- Cardiovascular manifestations of immune-mediated inflammatory Disorders.- Genetics and Genomics of Stroke.- Genetics and genomics of systemic hypertension.- Inherited pulmonary arterial hypertension.- Genetics and Genomics of Sudden Unexplained Cardiac Death.- Specific issues in clinical genetics and genetic counselling practices related to inherited cardiovascular conditions.- Multidisciplinary management for inherited cardiovascular conditions.- Internal devices and interventions for inherited cardiac conditions.- Inherited cardiovascular conditions:phenotype-genotype data mining and sharing; databases.
Over de auteur
Professor Dhavendra Kumar is a Consultant in Clinical Genetics at the University Hospital of Wales, Cardiff University, United Kingdom. He is the lead Clinical Geneticist for Clinical Cardiovascular Genetics. He is the Visiting Professor to the Genomic Policy Unit at the University of South Wales, UK, the Adjunct Professor to the Public Health Genetics Unit at the Chinese Capital Medical University, Beijing (China) and Visiting Professor/ Chief Guest of the prestigious Ranbaxy Science Foundation, India.
Internationally renowned expert in cardiovascular genetics and genomics. Professor Perry Elliott is recognized for his lead contributions in different forms of inherited cardiomyopathies, particularly familial hypertrophic and dilated cardiomyopathy. His current roles include the Deputy Editor of the BMJ journal Heart and co-editor/author of Principles and Practice of Clinical Cardiovascular Genetics & Oxford Specialist Handbook Inherited Cardiac Disease.
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