This book presents all important aspects of modern alkaloid chemistry, making it the only work of its kind to offer up-to-date and comprehensive coverage. While the first part concentrates on the structure and biology of bioactive alkaloids, the second one analyzes new trends in alkaloid isolation and structure elucidation, as well as in alkaloid synthesis and biosynthesis.
A must for biochemists, organic, natural products, and medicinal chemists, as well as pharmacologists, pharmaceutists, and those working in the pharmaceutical industry.
Inhoudsopgave
Preface
BIOACTIVE ALKALOIDS: STRUCTURE AND BIOLOGY
Ecological Roles of Alkaloids
Antitumor Alkaloids in Clinical Use or in Clinical Trials
Alkaloids and the Bitter Taste
Capsaicin and Capsaicinoids
Glycosidase-Inhibiting Alkaloids: Isolation, Structure, and Application
Neurotoxic Alkaloids from Cyanobacteria
Lamellarin Alkaloids: Structure and Pharmacological Properties
Manzamine Alkaloids
Antiangiogenic Alkaloids from Marine Organisms
A Typical Class of Marine Alkaloids: Bromopyrroles
Guanidine Alkaloids from Marine Invertebrates
NEW TRENDS IN ALKALOID ISOLATION AND STRUCTURE ELUCIDATION
Analysis of Tropane Alkaloids in Biological Matrices
LC-MS of Alkaloids: Qualitative Profiling, Quantitative Analysis, and Structural Identification
Applications of 15NNMR Spectroscopy in Alkaloid Chemistry
NEW TRENDS IN ALKALOID SYNTHESIS
Synthesis of Alkaloids by Transition Metal Mediated Oxidative Cyclizations
Camptothecin and Analogues: Structure and Synthetic Efforts
Combinatorial Synthesis of Alkaloid-like Compounds In Search of Chemical Probes of Protein-Protein Interactions
Daphniphyllum Alkaloids: Structures, Biogenesis, and Activities
Structure and Biosynthesis of Halogenated Alkaloids
Engineering Biosynthetic Pathways to Generate Indolocarbazole Alkaloids in Microorganisms
Over de auteur
Ernesto Fattorusso was assistant professor at the University of Naples (1963-75); in 1975 he became full Professor of Organic Chemistry at the Faculty of Science. In 1980 he moved to the Faculty of Pharmacy, where he was elected Dean twice. In 2002 he won the A. Quilico Award (Società Chimica Italiana) and in 2004 the P. Scheuer Award (Akademie of Erfurt). He has published more than 300 research papers.
Orazio Taglialatela Scafati got the Ph.D. in ‘Bioactive Natural Products’ in 1997, under the supervision of Prof. Fattorusso. Currently, he is Associate Professor in Organic Chemistry, Faculty of Pharmacy, University of Naples ‘Federico II’.
His research interests deal with isolation, structure elucidation and semisynthetic transformations of bioactive secondary metabolites from marine invertebrates and terrestrial plants. He is the author of 45 research papers and the editor of the book ‘Flavour and Fragrance Chemistry’.
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